Title:
【発明の名称】混合主鎖オリゴマー化合物の合成のための化合物、方法及び中間体
Document Type and Number:
Japanese Patent JP2002536453
Kind Code:
A
Abstract:
Synthetic processes are provided wherein mixed backbone oligomeric compounds are prepared having at least one phosphodiester internucleoside linkage in addition to one or more phosphorothioate, phosphoramidate and boranophosphate internucleoside linkages. Novel H-phosphonate intermediates are also disclosed that are useful in the synthetic processes. The synthetic processes use a novel oxidation step to oxidize H-phosphonate internucleoside linkages to phosphodiester internucleoside linkages without degradation of adjacent phosphorothioate, phosphoramidate and boranophosphate internucleoside linkages. Also provided are synthetic intermediates useful in such processes.
Inventors:
Manoharan, Mutia
Mayer, Martin A
Mayer, Martin A
Application Number:
JP2000598512A
Publication Date:
October 29, 2002
Filing Date:
February 11, 2000
Export Citation:
Assignee:
Isis PharmaceuticalsInc
International Classes:
C07F9/655; C07H19/10; C07H19/20; C07H21/00; (IPC1-7): C07H21/00; C07F9/655; C07H19/10; C07H19/20
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)