Title:
【発明の名称】抗腫瘍活性を有する複素環化合物
Document Type and Number:
Japanese Patent JP2002539114
Kind Code:
A
Abstract:
Compounds of general formula (I) in which: Y is O, S or NH; n is 0 or 1; X is selected from the group consisting of -NH-CO-NH, -NH-CO-, NH-SO2-, -NH-, -CO-NH-, -CO-NH-NH-, -NH-NH-CO-, -NH-NH-SO2-, -NH-CO-CO-, -NH-CO-CH2-, -NH-NH-,-NH-NH-CO-NH-, -NH-CO-NH-NH-, -CO-, -NH-SO2-NH-, -CO-NH-CO-NH-, -NH-CO-NH-CO-, -NH-CO-NH-SO2-, -NH-C(=NH)-NH-NH-, -NH-NH-C(=NH)-NH-, -CH=CH-, -CO-CH=CH-, -CH=CH-CO-, cyclopropan-1,2-di-yl, -NH-CH(COORC)-; R1 is selected from the group consisting of H, alkyl, -(CH2)p-A, wherein p = 0-4 and A = OH, -NRaRb, -COORc, -CONRaRb, -CONH(CH2)q-NRaRb, -CONH(CH2)q-COORc, wherein q = 1-4, Ra and Rb are H, alkyl, or Ra and Rb together with the nitrogen atom they are linked to form a 4-7 membered heterocyclic ring; Rc is H, alkyl or alkali or alkaline-earth metal; R is alkyl, cycloalkyl, arylalkyl, naphthyl, optionally substituted phenyl, aromatic or non aromatic 5 or 6 membered heterocyclic ring optionally benzofused; R2 is H or alkyl and the dotted line means an optional bond, for use as medicaments, in particular as antitumor agents.
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Inventors:
Mentor, Ernesto
Conti, Marco
Pescalli, Nicoletta
Conti, Marco
Pescalli, Nicoletta
Application Number:
JP2000604021A
Publication Date:
November 19, 2002
Filing Date:
March 01, 2000
Export Citation:
Assignee:
Nobu Pharma Sochieta Per Azioni
International Classes:
A61K31/341; A61K31/365; A61K31/366; A61K31/381; A61K31/4015; A61P1/00; A61P35/00; C07D207/36; C07D207/38; C07D307/58; C07D307/66; C07D309/32; C07D333/36; (IPC1-7): C07D207/36; A61P1/00; A61P35/00; C07D307/58; C07D307/66; C07D309/32; C07D333/36
Attorney, Agent or Firm:
Hajime Tsukuni (1 person outside)