Title:
【発明の名称】4-フルオロアルキル-3-ハロフェニルノルトロパン
Document Type and Number:
Japanese Patent JP2002542306
Kind Code:
A
Abstract:
A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes family are described as diagnostic and therapeutic agents for diseases associated with serotonin transporter dysfunction. These compounds bind to serotonin transporter protein with high affinity and selectivity. The invention provides methods of synthesis which incorporate radioisotopic halogens at a last step which permit high radiochemical yield and maximum usable product life. The radiolabeled compounds of the invention are useful as imaging agents for visualizing the location and density of serotonin transporter by PET and SPECT imaging.
Inventors:
Goodman, Mark M.
Chain pin
Chain pin
Application Number:
JP2000613481A
Publication Date:
December 10, 2002
Filing Date:
April 26, 2000
Export Citation:
Assignee:
Emory University
International Classes:
C07D471/08; A61K49/04; A61K49/06; A61K51/00; A61K51/04; C07D451/02; (IPC1-7): C07D471/08; A61K51/00
Attorney, Agent or Firm:
Shusaku Yamamoto