Title:
【発明の名称】環状尿素および環状アミド誘導体を用いた周期的管理
Document Type and Number:
Japanese Patent JP2002543119
Kind Code:
A
Abstract:
This invention concerns cyclic combination therapies using progestational agents and indoline derivatives which are progesterone receptor antagonists of the general structure:wherein: A, B and D are N or CH, though not all can be CH; R1 and R2 are H, CORA, NRBCORA, or optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, or aryl groups; or R1 and R2 form a spirocyclic ring; RA is H or optionally substituted alkyl aryl, alkoxy, or aminoalkyl; RB is H, alkyl alkyl; R3 is H, OH, NH2, alkyl, alkenyl, or CORC; RC is H, alkyl, aryl, alkoxy, or aminoalkyl; R4 is benzene or a 5 or 6 membered heteroaromatic ring; RF is H, alkyl, aryl, alkoxy, or aminoalkyl; RG is H or alkyl; R5 is H or alkyl; W is O or a chemical bond; or a pharmaceutically acceptable salt thereof. These methods may be used for contraception.
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Inventors:
Glove, Gary S
The Rin
Todd Kay, The Jones
Tegley, Christopher M
Pueng, Tuang
Frentham, Andrew
Viet, Andrew Kyu
Santeira, Arthur A
Telefuenko, Eugene A.
Blobell, Jee Yee
Edwards, The Ames P
The Rin
Todd Kay, The Jones
Tegley, Christopher M
Pueng, Tuang
Frentham, Andrew
Viet, Andrew Kyu
Santeira, Arthur A
Telefuenko, Eugene A.
Blobell, Jee Yee
Edwards, The Ames P
Application Number:
JP2000614988A
Publication Date:
December 17, 2002
Filing Date:
May 01, 2000
Export Citation:
Assignee:
Wyeth
Ligand Pharmaceuticals Incorporated
Ligand Pharmaceuticals Incorporated
International Classes:
C07D498/04; A61K31/5365; A61K31/565; A61K31/57; A61K45/06; A61P5/32; A61P5/36; A61P15/08; A61P15/18; A61P35/00; (IPC1-7): C07D498/04; A61K31/5365; A61K31/57; A61P5/32; A61P5/36; A61P15/08; A61P15/18; A61P35/00
Attorney, Agent or Firm:
Heiyoshi Odashima