Title:
【発明の名称】造影剤
Document Type and Number:
Japanese Patent JP2002543175
Kind Code:
A
Abstract:
The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents of formula Iwherein n is 0 or 1, and where n is 1 each C6R5 moiety may be the same or different; X denotes a bond or a group providing a 1 to 7 atom chain linking two C6R5 moieties or, where n is 0, X denotes a group R; each group R is a hydrogen atom, an iodine atom or a hydrophilic moiety M or M1, two or three non-adjacent R groups in each C6R5 moiety being iodine and at least one R group in each C6R5 moiety being an M or M1 moiety; each M which may be the same or different, is a non-ionic hydrophilic moiety; and each M1 independently represents a -CHOHCON(R1)2 group wherein each R1, which may be the same or different, is a hydrogen atom, an OH group or a C1-6 alkoxy or optionally hydroxylated C1-5 alkyl group; at least one R group in the molecule being an M1 moiety; and isomers thereof.
Inventors:
Ek, Frederick
Almen, Torsten
Almen, Torsten
Application Number:
JP2000615375A
Publication Date:
December 17, 2002
Filing Date:
April 28, 2000
Export Citation:
Assignee:
Amersham Health AS
International Classes:
C07C229/64; C07C235/16; C07C237/20; C07C237/22; C07C237/46; C07C275/50; C07C275/54; A61K49/04; (IPC1-7): C07C229/64; A61K49/04; C07C235/16; C07C237/20; C07C237/46; C07C275/50; C07C275/54
Domestic Patent References:
| JPH10505856A | 1998-06-09 | |||
| JPH10505857A | 1998-06-09 |
Other References:
JPN6010018146, Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ, Ｖｏｌ．８１， Ｎｏ．７, ｐ．３７１ （１９７４）．
Attorney, Agent or Firm:
Takehiko Suzue (4 outside)