Title:
【発明の名称】インテグリンのその受容体への結合を阻害するカルボン酸誘導体
Document Type and Number:
Japanese Patent JP2002544161
Kind Code:
A
Abstract:
A method for the inhibition of the binding of alpha 4 beta 1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and to the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which alpha 4 beta 1 is involved.
Inventors:
Ronald Theei, Beidagar
Chi, chi
Holland, the George D'Abri
Kasil, Jiamal M
Lee, Wen
Robert Buoy, Market
Ian El, Scott
Woo, Ji
Chi, chi
Holland, the George D'Abri
Kasil, Jiamal M
Lee, Wen
Robert Buoy, Market
Ian El, Scott
Woo, Ji
Application Number:
JP2000616772A
Publication Date:
December 24, 2002
Filing Date:
May 05, 2000
Export Citation:
Assignee:
Texas Biotechnology Corporation
International Classes:
C07D239/36; A61K31/215; A61K31/216; A61K31/335; A61K31/357; A61K31/36; A61K31/38; A61K31/381; A61K31/4015; A61K31/4025; A61K31/44; A61K31/4409; A61K31/4412; A61K31/4427; A61K31/445; A61K31/4523; A61K31/47; A61K31/506; A61K31/55; A61P1/00; A61P3/10; A61P9/10; A61P11/06; A61P17/00; A61P19/00; A61P19/02; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P43/00; C07C69/66; C07C275/32; C07C275/34; C07D207/04; C07D207/18; C07D207/416; C07D211/68; C07D211/72; C07D213/02; C07D213/64; C07D213/69; C07D213/73; C07D213/74; C07D213/75; C07D215/00; C07D215/38; C07D221/04; C07D233/96; C07D239/46; C07D239/47; C07D317/58; C07D333/20; C07D401/06; C07D405/12; C07D409/12; C07D409/14; C07D471/04; C07D487/04; (IPC1-7): C07C275/34; A61K31/216; A61K31/36; A61K31/381; A61K31/4015; A61K31/4025; A61K31/4409; A61K31/4412; A61K31/47; A61K31/55; A61P1/00; A61P3/10; A61P9/10; A61P11/06; A61P17/00; A61P19/02; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P43/00; C07D207/416; C07D213/64; C07D213/69; C07D213/73; C07D213/74; C07D213/75; C07D215/38; C07D239/36; C07D239/47; C07D317/58; C07D333/20; C07D405/12; C07D409/14; C07D487/04
Domestic Patent References:
| JPH07304755A | 1995-11-21 | |||
| JPH05255279A | 1993-10-05 | |||
| JP2000510700A | 2000-08-22 | |||
| JP2001500875A | 2001-01-23 |
Foreign References:
| US5770573A | 1998-06-23 | |||
| WO1997043650A1 | 1997-11-20 | |||
| WO1998011896A1 | 1998-03-26 | |||
| US5721366A | 1998-02-24 |
Attorney, Agent or Firm:
Yoshio Kawaguchi (5 outside)