Title:
【発明の名称】α-アミノ-β-スルホニルヒドロキサム酸化合物
Document Type and Number:
Japanese Patent JP2003500389
Kind Code:
A
Abstract:
A family of molecules is disclosed that inhibit matrix metalloprotease (MMP) activity, and particularly inhibit the activity of one or more of MMP-2, MMP-9, or MMP-13, while generally exhibiting little activity against MMP-1. A contemplated compound also exhibits little inhibition of the production of TNF. A contemplated compound is an alpha-amino-beta-sulfonyl carbocyclo, heterocyclo, aryl, or heteroaryl hydroxamic acid. Also disclosed are processes for preparing a contemplated compound and for treating a mammal having a condition associated with pathological matrix metalloprotease activity.
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Inventors:
Bata, Thomas Y
Becker, Daniel Pea
Bedel, Louis Jay
De Cresenzo, Gary A.
Frescos, John N
Getman, Daniel Pea
Heinz, Robert M
Hookerman, Susan El
Lee, Hoy
Brent buoy, misc
Villa Mill, Clara Eye
Becker, Daniel Pea
Bedel, Louis Jay
De Cresenzo, Gary A.
Frescos, John N
Getman, Daniel Pea
Heinz, Robert M
Hookerman, Susan El
Lee, Hoy
Brent buoy, misc
Villa Mill, Clara Eye
Application Number:
JP2000619771A
Publication Date:
January 07, 2003
Filing Date:
May 17, 2000
Export Citation:
Assignee:
G.D.Searl and Company
International Classes:
A61K31/16; A61K31/164; A61K31/166; A61K31/17; A61K31/18; A61K31/197; A61K31/222; A61K31/27; A61K31/341; A61K31/351; A61K31/4409; A61K31/4453; A61K31/47; A61P1/02; A61P1/04; A61P7/00; A61P7/02; A61P11/00; A61P13/12; A61P17/02; A61P19/00; A61P19/02; A61P25/28; A61P27/02; A61P29/00; A61P35/04; A61P43/00; C07C317/48; C07C317/50; C07C323/65; C07D207/09; C07D211/14; C07D213/38; C07D307/58; C07D215/50; C07D307/68; C07D309/10; C07K5/06; A61K38/00; (IPC1-7): C07C317/50; A61K31/16; A61K31/164; A61K31/166; A61K31/17; A61K31/18; A61K31/197; A61K31/222; A61K31/27; A61K31/341; A61K31/351; A61K31/4409; A61K31/4453; A61K31/47; A61P1/02; A61P1/04; A61P7/02; A61P13/12; A61P17/02; A61P19/00; A61P19/02; A61P25/28; A61P27/02; A61P29/00; A61P35/04; A61P43/00; C07C317/48; C07C323/65; C07D207/09; C07D211/14; C07D213/38; C07D215/50; C07D307/68; C07D309/10
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)