Title:
【発明の名称】脈管形成インヒビターとしてのC-CAM
Document Type and Number:
Japanese Patent JP2003501362
Kind Code:
A
Abstract:
The present invention relates generally to the fields hyperproliferative disease and angiogenesis. More particularly, the present invention demonstrates that a C-CAM1 cytoplasmic domain is necessary and sufficient for inhibiting angiogenesis. In particular embodiments, it relates to inhibiting hyperproliferative cell growth by administering to a cell a C-CAM1 cytoplasmic domain or an expression construct encoding a C-CAM1 cytoplasmic domain. In other embodiments, angiogenesis is inhibited by administering to a subject a C-CAM1 polypeptide or an expression construct encoding a C-CAM1 polypeptide.
Inventors:
Lynn, Suehwa
Luo, Wapin
Logo zetis, christopher
Luo, Wapin
Logo zetis, christopher
Application Number:
JP2001500664A
Publication Date:
January 14, 2003
Filing Date:
May 26, 2000
Export Citation:
Assignee:
Board of Regents, The University of Texas System
International Classes:
A61K35/76; A61K38/00; A61K48/00; A61P35/00; A61P43/00; C07K14/705; C12N15/09; (IPC1-7): A61K38/00; A61K35/76; A61K48/00; A61P35/00; A61P43/00; C07K14/705; C12N15/09
Attorney, Agent or Firm:
Shusaku Yamamoto