Title:
【発明の名称】表面修飾法、新規マトリックスおよび該マトリックスの使用
Document Type and Number:
Japanese Patent JP2003501521
Kind Code:
A
Abstract:
A method for hydrophilization and/or surface area enlargement of a porous base matrix comprising on its inner and/or outer surfaces a polymer (P') carrying nucleophilic groups X'. The method is characterized in (a) ethoxylating a plurality of said X' thereby transforming them to groups comprising -(CH2CH2O)nH, or (b) (i) ethoxylating a polymer (P'') carrying nucleophilic groups X'' thereby transforming P'' to a polyhydroxy polymer (P''') carrying a plurality of -(CH2CH2O)nH groups, whereafter (ii) P''' is attached to the base matrix. n is an integer >=1. A support matrix which is obtainable by the method. The support matrix has a sufficient rigidity and swellability to permit liquid flow of a velocity >5 cm/h through the matrix when in form of particles packed to a bed or in form of a porous monolithic plug. The use of the support matrix defined in liquid chromatography, cell culturing, stepwise solid phase synthesis of organic molecules, affinity adsorption in suspensions, solid phase catalysis with an immobilized catalyst.
Inventors:
Helene Deland
Jan Nasman
Jan Nasman
Application Number:
JP2001502475A
Publication Date:
January 14, 2003
Filing Date:
June 06, 2000
Export Citation:
Assignee:
Amersham Biosciences Aktiebolag
International Classes:
B01D15/08; B01J31/06; B01J32/00; B01J35/10; C08F8/00; C08G65/08; C08G81/02; C12N11/08; (IPC1-7): C08F8/00; B01D15/08; B01J31/06; B01J32/00; B01J35/10; C08G65/08; C08G81/02; C12N5/06; C12N11/08
Domestic Patent References:
| JPS6317904A | 1988-01-25 | |||
| JP2002520436A | 2002-07-09 | |||
| JP2000504368A | 2000-04-11 | |||
| JPS56125402A | 1981-10-01 | |||
| JPS61171712A | 1986-08-02 | |||
| JPS60217204A | 1985-10-30 |
Foreign References:
| US5466758A | 1995-11-14 |
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)