Title:
【発明の名称】ロイコトリエンB4受容体のトランスジェニック哺乳動物
Document Type and Number:
Japanese Patent JP2003505009
Kind Code:
A
Abstract:
The present invention describes a non-human transgenic mouse that produces in its leukocytes, a recombinant human leukotriene B4 receptor (BLTR), having physiological activity of human BLTR. The transgenic mouse has stably integrated into its genome an exogenous gene construct which includes (A) 5' expression regulating sequences, including a BLTR specific promoter, (B) DNA encoding the BLTR and a signal sequence effective in directing overexpression of the BLTR into leukocytes of the transgenic mouse and (C) 3' regulatory sequences that result in the overexpression of the DNA in the leukocytes. In one embodiment, (A), (B), and (C) are operably linked in the gene construct to obtain production of the BLTR in the leukocytes and overexpression thereof in the transgenic mouse.
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Inventors:
Sirhan, Charles N
Application Number:
JP2000604675A
Publication Date:
February 12, 2003
Filing Date:
March 14, 2000
Export Citation:
Assignee:
Brigham and Women's Hospital
International Classes:
C07K14/705; C12N5/10; C12N15/09; C12N15/63; C12N15/85; C12P21/02; C12Q1/02; A01K67/027; G01N33/15; G01N33/50; (IPC1-7): A01K67/027; C12N5/10; C12N15/09; C12P21/02; C12Q1/02; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Heiyoshi Odashima