Title:
【発明の名称】新規な2-デカルボキシ-2-ホスフィニコプロスタグランジンF類似体
Document Type and Number:
Japanese Patent JP2003506454
Kind Code:
A
Abstract:
The invention provides novel Prostaglandin F analogs. In particular, the present invention is directed to compounds having a structure according to the following formula:wherein R1, R2, X, Y, V, a, b, W, and Z are defined below.This invention also includes optical isomers, diastereomers and enantiomers of the formula above, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof.The compounds of the present invention are useful for the treatment of a variety of diseases and conditions, such as bone disorders and glaucoma. Accordingly, the invention further provides pharmaceutical compositions comprising these compounds. The invention still further provides methods of treatment for bone disorders and glaucoma using these compounds or the compositions containing them.
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Inventors:
Mitchell Anthony Delong
John August Was
Biswanus de
Frank Hallock Ebetino
John August Was
Biswanus de
Frank Hallock Ebetino
Application Number:
JP2001515681A
Publication Date:
February 18, 2003
Filing Date:
August 01, 2000
Export Citation:
Assignee:
THE PROCTER & GAMBLE COMPANY
International Classes:
A61K31/665; A61K31/67; A61P19/00; A61P19/08; A61P19/10; A61P27/06; C07F9/30; A61K31/662; (IPC1-7): C07F9/30; A61K31/662; A61K31/665; A61K31/67; A61P19/00; A61P19/08; A61P19/10; A61P27/06
Foreign References:
| WO1999012895A1 | 1999-03-18 | |||
| WO1999012896A1 | 1999-03-18 | |||
| WO1999012898A1 | 1999-03-18 |
Other References:
KLUENDER H C, PROSTAGLANDINS MED., vol. V2 N6, JPN5002011191, 1979, pages 441 - 444, ISSN: 0002022932
Attorney, Agent or Firm:
Yoshikazu Tani (2 outside)