Title:
【発明の名称】徐放性鎮静催眠組成物およびそれに関連する方法
Document Type and Number:
Japanese Patent JP2003507413
Kind Code:
A
Abstract:
Controlled-release formulations providing a "pulsed" plasma profile of a sedative-hypnotic compounds having a particularly short half-life are provided. The formulation contains a sedative-hypnotic compound or precursor thereof that is metabolized to generate a sedative-hypnotic compound in vivo, wherein the compound has a mean plasma half life ranging from 0.1 to 2 hours; and at least one release retardant such that, following administration of the formulation to a patient, the patient has specific pulsed plasma profile for the sedative-hypnotic compound as disclosed herein. In a preferred embodiment, the sedative-hypnotic compound is NBI-34060.
Inventors:
Campbell, Dee. Brass
Ciel, W. Jay
Ciel, W. Jay
Application Number:
JP2001518033A
Publication Date:
February 25, 2003
Filing Date:
August 28, 2000
Export Citation:
Assignee:
Neurocline Biosciences, Inc.
International Classes:
A61K9/22; A61K9/24; A61K9/50; A61K9/52; A61K31/519; A61K47/10; A61K47/14; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/44; A61P25/20; C07D487/04; (IPC1-7): A61K9/22; A61K31/519; A61K47/10; A61K47/14; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/44; A61P25/20
Foreign References:
| US4654347A | 1987-03-31 | |||
| WO2001010868A1 | 2001-02-15 | |||
| US4654347A | 1987-03-31 | |||
| WO2001010868A1 | 2001-02-15 |
Attorney, Agent or Firm:
Shusaku Yamamoto