Title:
【発明の名称】徐放される経口医薬投薬形
Document Type and Number:
Japanese Patent JP2003508428
Kind Code:
A
Abstract:
A partially delayed oral pharmaceutical dosage form (A) comprising tramadol (I) as active agent, (I) is at least partially in the form of a compound (I') formed in situ and having at water solubility of 50 mg/ml or less (especially 5 mg/ml or less). An independent claim is included for the preparation of (A), by mixing tramadol (I) with an acidic drug or auxiliary (II) (or its water-soluble salt) and optionally auxiliaries, wetting and formulating with application of energy.
Inventors:
Ziegrel Iris
Baltic Horomeus Johannes
Baltic Horomeus Johannes
Application Number:
JP2001519895A
Publication Date:
March 04, 2003
Filing Date:
August 03, 2000
Export Citation:
Assignee:
Grunenthal Gesellschaft Mito Beschlenktel Haftung
International Classes:
A61K9/20; A61K9/22; A61K9/28; A61K9/30; A61K9/50; A61K9/52; A61K31/135; A61K31/19; A61K31/192; A61K31/195; A61K31/196; A61K31/428; A61K31/60; A61K31/616; A61K47/12; A61K47/20; A61K47/22; A61P1/04; A61P1/12; A61P9/00; A61P11/00; A61P11/14; A61P13/00; A61P13/02; A61K9/16; A61P25/00; A61P25/08; A61P25/18; A61P25/24; A61P25/30; A61P25/32; A61P25/36; A61P29/00; A61P37/08; (IPC1-7): A61K31/135; A61K9/16; A61K9/22; A61K9/30; A61K9/52; A61K31/192; A61K31/196; A61K31/616; A61K47/12; A61K47/20; A61K47/22; A61P1/04; A61P1/12; A61P9/00; A61P11/00; A61P11/14; A61P13/02; A61P25/08; A61P25/18; A61P25/24; A61P25/30; A61P25/32; A61P29/00
Attorney, Agent or Firm:
Mitsufumi Ezaki (3 others)