Title:
【発明の名称】ピリミド〔5,4-g〕プテリジン誘導体の製造方法
Document Type and Number:
Japanese Patent JP2003512376
Kind Code:
A
Abstract:
Preparation of pyrimido[5,4-g]pteridine of formula Iwherein A1, A2, A3 and A4 are each independently of the others -NR1R2, wherein R1 and R2 are hydrogen, C1-C8alkyl, -CO-C1-C8alkyl, -CO-C6-C14aryl, -COO-C1-C8alkyl, -COO-C6-C14aryl, -CONH-C1-C8alkyl or -CONH-C6-C14aryl, or -OH, -SH, hydrogen, C1-C8alkyl, C1-C8alkoxy, or C6-C14aryl or -O-C6-C14aryl each unsubstituted or mono- or poly-substituted by halogen, nitro, cyano, -OR10, -SR10, -NR10R11, -CONR10R11, -COOR10, -SO2R10, -SO2NR10R11, -SO3R10, -NR11COR10 or by -NR11COOR10, wherein R10 and R11 are each independently of the other hydrogen, C1-C8alkyl, C5-C12cycloalkyl or C2-C8alkenyl, by a) reacting the pyrimidine of formula IIwith the pyrimidine of formula IIIin the presence of an acid and, if desired, of a solvent, the molar ratio of the acid to the compound of formula II being in the range of from 100:1 to 1:1, and b) subsequently treating the resulting reaction mixture with a base, and novel pyrimido[5,4-g]pteridine salts and their use.
Inventors:
Eichenberger, Thomas
Fujing, max
Muller, Karl-Heinz
Fujing, max
Muller, Karl-Heinz
Application Number:
JP2001531838A
Publication Date:
April 02, 2003
Filing Date:
October 12, 2000
Export Citation:
Assignee:
Ciba Specialty Chemicals Holding Incorporated
International Classes:
C07B61/00; C07D487/14; C08K5/24; C08L101/00; C09B17/00; C09B57/00; (IPC1-7): C07D487/14; C08K5/24; C08L101/00
Attorney, Agent or Firm:
Hajime Tsukuni (1 person outside)