Title:
【発明の名称】免疫治療で使用される修飾ペプチドおよびペプチド模倣体
Document Type and Number:
Japanese Patent JP2003512388
Kind Code:
A
Abstract:
The invention relates to a modified peptide derived from H-Arg-Ser-Phe-Thr-Leu-Ala-Ser-Ser-Glu-Thr-Gly-Val-Gly-OH having general formula (II): Q-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-Z. In general formula (II), A1 through A13 correspond with the amino acids of formula (I), Q corresponds with H and Z corresponds with OH. The modifications according to the present invention are selected one or more of the groups a, b or c, consisting of a) substitution of 1-6, preferably 1-4 amino acids at A1 through A13 with non-natural amino acids or beta amino acids; b) substitution of one or more amide bonds with reduced amide bonds or ethylene isosteres; c) substitutions at Q and/or Z and, optionally, d) substitution of natural amino acids up to a total of 6 modifications. The peptides can be used for inducing tolerance induction in patients suffering from autoimmune diseases.
Inventors:
Juan Stahualen, Catalina Yoanna
Tameels, Cornelis Marius
Haren Juan, Philipps Johannes Marie
Kneftel, Lunardos Marcelius Alphons
Boats, Anna Maria Helena
Miltenburg, Andreas Martinus Maria
Tameels, Cornelis Marius
Haren Juan, Philipps Johannes Marie
Kneftel, Lunardos Marcelius Alphons
Boats, Anna Maria Helena
Miltenburg, Andreas Martinus Maria
Application Number:
JP2001531879A
Publication Date:
April 02, 2003
Filing Date:
October 12, 2000
Export Citation:
Assignee:
Akzo Novel N B
International Classes:
A61K38/10; A61K39/00; A61P19/02; A61K38/00; A61P37/06; C07K7/00; C07K14/47; G01N33/68; A61K38/095; (IPC1-7): C07K7/00; A61K38/00; A61P37/06
Attorney, Agent or Firm:
Yoshio Kawaguchi (4 outside)