Title:
【発明の名称】ケトイミンの調製方法
Document Type and Number:
Japanese Patent JP2003514794
Kind Code:
A
Abstract:
Described is a process for the preparation of compounds of formula (1a) which comprises reacting an isomeric mixture consisting of from 75 to 95% of compound of formula (2a) and from 5 to 25% of a compound of formula (2b) with methylamine, in a suitable solvent, to form a sertraline-imine isomeric mixture consisting of from 75 to 95% of formula (1a) and from 5 to 25% of formula (1b)(A1), or reacting an isomeric mixture consisting of from 75 to 95% of a compound of formula (2a) and from 5 to 25% of a compound of formula (2b) with methylamine, in a suitable solvent, using suitable methods of isolation to form an enriched sertraline-imine isomeric mixture, consisting of >99% of a compound of formula (1a) and <1% of a compound of formula (1b)(A2); and then subjecting the sertraline-imine isomeric mixture obtained according to reaction route (A1) or (A2), in a suitable solvent, to recrystallisation (B), in accordance with scheme (I) wherein in formula (1a), R1, R2 and R3 are each independently of the others hydrogen, halogen, trifluoromethyl or C1-C4alkoxy and formulae (1b), (2a) and (2b) are as defined in the description.
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Inventors:
Marc, tomen
Hafner, Andreas
Collie, romance
Kirner, Hans-Jörg
Brünné, Frederick
Hafner, Andreas
Collie, romance
Kirner, Hans-Jörg
Brünné, Frederick
Application Number:
JP2001538869A
Publication Date:
April 22, 2003
Filing Date:
November 07, 2000
Export Citation:
Assignee:
Ciba Specialty Chemicals Holding Incorporated
International Classes:
C07B61/00; C07C249/02; C07C251/20; (IPC1-7): C07C249/02; C07C251/20
Foreign References:
| WO1999036394A1 | 1999-07-22 | |||
| WO1998015516A1 | 1998-04-16 |
Attorney, Agent or Firm:
Hajime Tsukuni (1 person outside)