Title:
【発明の名称】化学的方法および中間体
Document Type and Number:
Japanese Patent JP2003515539
Kind Code:
A
Abstract:
The invention relates to chemical processes and chemical intermediates which are useful in the selective formation of a primary mono-phosphoryl group (-OPO(OH2)) in a terminal 1,2-diol-propanoyl (HO-CH2CH(OH)-CO-) containing system, and to chemical processes and chemical intermediates (and processes for their manufacture) particularly useful for the manufacture of anti-Gram positive oxazolidinone bacterial agents containing such functionality, in particular for the preparation of 5(R)-Isoxazol-3-yloxymethyl-3-(4-(1-(2(S) -hychoxy-3-phosphoryl-propanoyl)-1,2,5,6-tetrahydropyridy-4-il)3,5-difluorophenyl)oxazolidin-2-one.
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Inventors:
Gravestock, Michael Berry
Kenneth Edwin Herbert, Warren
Ennis, David Simon
Curie, Angela Charlotte
Einje, Debra
Kenneth Edwin Herbert, Warren
Ennis, David Simon
Curie, Angela Charlotte
Einje, Debra
Application Number:
JP2001540991A
Publication Date:
May 07, 2003
Filing Date:
November 28, 2000
Export Citation:
Assignee:
AstraZeneca Activrag
International Classes:
C07D413/12; C07D413/14; C07F9/09; C07F9/6518; C07F9/6558; C07F9/6574; (IPC1-7): C07F9/6518; C07D413/12; C07D413/14
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)