Title:
【発明の名称】抗ピコルナウイルス化合物及び組成物、その医薬的使用及びその合成のための物質
Document Type and Number:
Japanese Patent JP2003515591
Kind Code:
A
Abstract:
Compounds of the formula:where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the picornaviral 3C protease. Also disclosed are compounds of the formula:where the formula variables are as defined herein that advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as rhinovirus 3C proteases. Intermediates and synthetic methods for preparing such compounds are also described.
Inventors:
Dragovich, Peter Es
Prince, Thomas Jay
Butterfly, roux
Johnson, Theodore O. Jr.
Prince, Thomas Jay
Butterfly, roux
Johnson, Theodore O. Jr.
Application Number:
JP2001541874A
Publication Date:
May 07, 2003
Filing Date:
December 01, 2000
Export Citation:
Assignee:
Agron Pharmaceuticals Incorporated
International Classes:
A61K31/437; A61K31/44; A61K31/4412; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4436; A61K31/4439; A61K31/444; A61P31/12; A61P31/14; A61P31/16; A61P43/00; C07D213/75; C07D401/12; C07D405/12; C07D405/14; C07D409/12; C07D413/12; C07D413/14; C07D471/04; C07D; (IPC1-7): C07D213/75; A61K31/437; A61K31/4412; A61K31/443; A61K31/4436; A61K31/4439; A61K31/444; A61P31/14; A61P43/00; C07D401/12; C07D405/12; C07D405/14; C07D409/12; C07D413/12; C07D413/14; C07D471/04
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)