Title:
【発明の名称】ヘッジホッグ経路の調節物質、並びにそれに関する組成物及び利用法
Document Type and Number:
Japanese Patent JP2003516317
Kind Code:
A
Abstract:
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.
Inventors:
Beachy Philip A
Application Number:
JP2001530353A
Publication Date:
May 13, 2003
Filing Date:
October 13, 2000
Export Citation:
Assignee:
JOHNS HOPKINS UNIVERSITY
International Classes:
A61K31/58; A61P1/02; A61P1/16; A61P1/18; A61P11/00; A61P15/16; A61P15/18; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P17/08; A61P17/12; A61P17/14; A61P17/16; A61P19/02; A61P19/04; A61P19/08; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/28; A61P27/00; A61P27/12; A61P35/00; A61P43/00; C07J69/00; (IPC1-7): C07J69/00; A61K31/58; A61P1/02; A61P1/16; A61P1/18; A61P11/00; A61P15/16; A61P15/18; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P17/08; A61P17/12; A61P17/14; A61P17/16; A61P19/02; A61P19/04; A61P19/08; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/28; A61P27/00; A61P27/12; A61P35/00; A61P43/00
Domestic Patent References:
| JP2002511415A | 2002-04-16 |
Other References:
JPN6009061950; ＣＯＯＰＥＲ， Ｍ． Ｋ． ｅｔ ａｌ．: 'Ｔｅｒａｔｏｇｅｎ-Ｍｅｄｉａｔｅｄ Ｉｎｈｉｂｉｔｉｏｎ ｏｆ Ｔａｒｇｅｔ Ｔｉｓｓｕｅ Ｒｅｓｐｏｎｓｅ ｔｏ Ｓｈｈ Ｓｉｇｎａｌｉｎｇ' Ｓｃｉｅｎｃｅ Ｖｏｌ．２８０, 19980605, ｐ． １６０３-１６０７
JPN6009061951; Ｉｎｃａｒｄｏｎａ ＪＰ: 'Ｔｈｅ ｔｅｒａｔｏｇｅｎｉｃ Ｖｅｒａｔｒｕｍ ａｌｋａｌｏｉｄ ｃｙｃｌｏｐａｍｉｎｅ ｉｎｈｉｂｉｔｓ ｓｏｎｉｃ ｈｅｄｇｅｈｏｇ ｓｉｇｎａｌ ｔｒａｎｓｄｕｃｔｉｏｎ' Ｄｅｖｅｌｏｐｍｅｎｔ Ｖｏｌ．１２５， Ｎｏ．１８, 199809, ｐ．３５５３-３５６２
JPN6011003112; Ｃｅｌｌｕｌａｒ ａｎｄ Ｍｏｌｅｃｕｌａｒ Ｂｉｏｌｏｇｙ Ｖｏｌ．４５， Ｎｏ．５, 199907, ｐ．５７９-５８８
JPN6009063059; ＫＩＭ， Ｓ． Ｋ． ｅｔ ａｌ．: 'Ｐａｎｃｒｅａｓ ｄｅｖｅｌｏｐｍｅｎｔ ｉｓ ｐｒｏｍｏｔｅｄ ｂｙ ｃｙｃｌｏｐａｍｉｎｅ， ａ Ｈｅｄｇｅｈｏｇｓｉｇｎａｌｉｎｇ ｉｎｈｉｂｉｔｏｒ' Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． ＵＳＡ Ｖｏｌ． ９５, 199810, ｐｐ． １３０３６-１３０４１
JPN6011003110; Ｓｔｅｒｏｉｄｓ Ｖｏｌｕｍｅ １３， Ｉｓｓｕｅ ５, 1969
JPN6011003115; Ｊ． Ａｇｒｉｃ． Ｆｏｏｄ． Ｃｈｅｍ． Ｖｏｌ．２６， Ｎｏ．３, 1978, ｐ．５６４-５６６
JPN6009061949; ＧＡＩＬＡＮＩ， Ｍ．Ｒ． ｅｔ ａｌ．: 'Ｄｅｖｅｌｏｐｍｅｎｔａｌ ｇｅｎｅｓ ａｎｄ ｃａｎｃｅｒ： ｒｏｌｅ ｏｆ ｐａｔｃｈｅｄ ｉｎ ｂａｓａｌ ｃｅｌｌ ｃａｒｃｉｎｏｍａ ｏｆ ｔｈｅ ｓｋｉｎ' Ｊ Ｎａｔｌ Ｃａｎｃｅｒ Ｉｎｓｔ Ｖｏｌ．８９，Ｎｏ．１５, 19970806, ｐ．１１０３-１１０９
JPN6009061951; Ｉｎｃａｒｄｏｎａ ＪＰ: 'Ｔｈｅ ｔｅｒａｔｏｇｅｎｉｃ Ｖｅｒａｔｒｕｍ ａｌｋａｌｏｉｄ ｃｙｃｌｏｐａｍｉｎｅ ｉｎｈｉｂｉｔｓ ｓｏｎｉｃ ｈｅｄｇｅｈｏｇ ｓｉｇｎａｌ ｔｒａｎｓｄｕｃｔｉｏｎ' Ｄｅｖｅｌｏｐｍｅｎｔ Ｖｏｌ．１２５， Ｎｏ．１８, 199809, ｐ．３５５３-３５６２
JPN6011003112; Ｃｅｌｌｕｌａｒ ａｎｄ Ｍｏｌｅｃｕｌａｒ Ｂｉｏｌｏｇｙ Ｖｏｌ．４５， Ｎｏ．５, 199907, ｐ．５７９-５８８
JPN6009063059; ＫＩＭ， Ｓ． Ｋ． ｅｔ ａｌ．: 'Ｐａｎｃｒｅａｓ ｄｅｖｅｌｏｐｍｅｎｔ ｉｓ ｐｒｏｍｏｔｅｄ ｂｙ ｃｙｃｌｏｐａｍｉｎｅ， ａ Ｈｅｄｇｅｈｏｇｓｉｇｎａｌｉｎｇ ｉｎｈｉｂｉｔｏｒ' Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． ＵＳＡ Ｖｏｌ． ９５, 199810, ｐｐ． １３０３６-１３０４１
JPN6011003110; Ｓｔｅｒｏｉｄｓ Ｖｏｌｕｍｅ １３， Ｉｓｓｕｅ ５, 1969
JPN6011003115; Ｊ． Ａｇｒｉｃ． Ｆｏｏｄ． Ｃｈｅｍ． Ｖｏｌ．２６， Ｎｏ．３, 1978, ｐ．５６４-５６６
JPN6009061949; ＧＡＩＬＡＮＩ， Ｍ．Ｒ． ｅｔ ａｌ．: 'Ｄｅｖｅｌｏｐｍｅｎｔａｌ ｇｅｎｅｓ ａｎｄ ｃａｎｃｅｒ： ｒｏｌｅ ｏｆ ｐａｔｃｈｅｄ ｉｎ ｂａｓａｌ ｃｅｌｌ ｃａｒｃｉｎｏｍａ ｏｆ ｔｈｅ ｓｋｉｎ' Ｊ Ｎａｔｌ Ｃａｎｃｅｒ Ｉｎｓｔ Ｖｏｌ．８９，Ｎｏ．１５, 19970806, ｐ．１１０３-１１０９
Attorney, Agent or Firm:
Tsutomu Kanakubo