Title:
【発明の名称】環状アミノ酸の立体選択的合成方法
Document Type and Number:
Japanese Patent JP2003516378
Kind Code:
A
Abstract:
The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), inflammation especially arthritis, sleep disorders, premenstrual syndrome, and hot flashes. The invention provides novel routes to synthesize stereoselectively analogs of gabapentin (Neurontin3) of Formulas (I), (II), (III) and (IV) wherein R is C1-C10 alkyl or C3-C10 cycloalkyl and pharmaceutically acceptable salts thereof.
Inventors:
Justin Stephen Bryans
David Clive Breakmore
Sophie Caroline Williams
David Clive Breakmore
Sophie Caroline Williams
Application Number:
JP2001543492A
Publication Date:
May 13, 2003
Filing Date:
November 30, 2000
Export Citation:
Assignee:
Warner-Lambert Company
International Classes:
C07B53/00; C07B57/00; C07B61/00; C07C51/08; C07C51/347; C07C51/353; C07C51/377; C07C51/41; C07C51/43; C07C53/134; C07C57/46; C07C69/608; C07C69/616; C07C227/20; C07C227/32; C07C227/34; C07C229/28; C07C255/31; C07C255/41; C07C265/08; C07C271/12; (IPC1-7): C07C227/20; C07C51/347; C07C51/353; C07C51/377; C07C53/134; C07C57/46; C07C227/32; C07C227/34; C07C229/28
Attorney, Agent or Firm:
Chika Takagi (2 outside)