Title:
【発明の名称】置換フェニルアミジン、これらの化合物を含む医薬組成物及びこれらの調製方法
Document Type and Number:
Japanese Patent JP2003520791
Kind Code:
A
Abstract:
Phenylamidine compounds (I), their salts, tautomers or stereoisomers are new. Phenylamidine compounds of formula (I), their salts, tautomers or stereoisomers are new. [Image] R6OH, 1-18C alkoxycarbonyl, arylcarbonyl or aryl-(1-4C alkoxy)carbonyl; R7H, 1-8C alkyl, 4-7C cycloalkyl, phenyl-(1-4C alkyl) or R8-CO-OCHR9; R81-4C alkyl, 1-4C alkoxy, 3-7C cycloalkyl or 4-7C cycloalkoxy; R9H or 1-4C alkyl; All the aryl moieties described above are phenyl monosubstituted by R10, mono- di- or trisubstituted by R11 or monosubstituted by R10 and mono- or disubstituted by R11; R10CN, COOH, 1-4C alkoxycarbonyl, aminocarbonyl, 1-4C alkylaminocarbonyl, di-(2-4C alkyl)aminocarbonyl, 1-4C alkylsulfenyl, 1-4C alkylsulfinyl, 1-4C alkylsulfonyl, OH, 1-4C alkylsulfonyloxy, OCF3, NO2, NH2, mono- or di-(1-4C alkyl)amino, (1-4C alkyl)carbonylamino, N-(1-4C alkyl)-(1-4C alkyl)sulfonylamino, aminosulfonyl, mono- or di-(1-4C alkyl)aminosulfonyl or carbonyl substituted by a 5-7 membered alkyleneimino group whose 4-methylene group may be replaced by a heteroatom or hetero group; R11F, Cl, Br, I, alkyl, CF3 or 1-4C alkoxy; Or two adjacent R11 groups together form 3-5C alkylene, methylenedioxy or 1,3-butadien-1,4-ylene. - ACTIVITY : Thrombolytic; cerebroprotective; anticoagulant; cardiant; antiarteriosclerotic; osteopathic; cytostatic; vasotropic; antipsoriatic; antidiabetic; antiinflammatory. No biological data given. - MECHANISM OF ACTION : Antimetastatic.
Inventors:
Himmelsbach Frank
Gut brian
Gut brian
Application Number:
JP2001553755A
Publication Date:
July 08, 2003
Filing Date:
January 13, 2001
Export Citation:
Assignee:
Boehringer Ingelheim Pharma Comandito Gezelshaft
International Classes:
C07D295/14; A61K31/495; A61P7/02; A61P9/10; A61P19/08; A61P35/00; A61P43/00; C07D295/15; (IPC1-7): C07D295/14; A61K31/495; A61P7/02; A61P9/10; A61P19/08; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Minoru Nakamura (9 outside)