Title:
【発明の名称】Aβタンパク質生成の阻害剤としてのスクシノイルアミノベンゾジアゼピン
Document Type and Number:
Japanese Patent JP2003523932
Kind Code:
A
Abstract:
This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
Inventors:
Richard E. Olson
Application Number:
JP2000590572A
Publication Date:
August 12, 2003
Filing Date:
December 23, 1999
Export Citation:
Assignee:
DuPont Pharmaceuticals Company
International Classes:
A61K31/55; A61K31/551; A61K31/5513; A61P25/00; A61P25/28; A61P43/00; C07D223/16; C07D223/18; C07D243/12; C07D243/14; C07D243/24; C07D401/04; (IPC1-7): C07D223/16; A61K31/55; A61K31/551; A61K31/5513; A61P25/00; A61P25/28; A61P43/00; C07D223/18; C07D243/12; C07D243/14; C07D243/24; C07D401/04
Domestic Patent References:
| JP2003526603A | 2003-09-09 | |||
| JPH11502523A | 1999-03-02 | |||
| JPH09188631A | 1997-07-22 | |||
| JP2002241368A | 2002-08-28 |
Foreign References:
| WO1998028268A2 | 1998-07-02 |
Other References:
JPN6009012654, Ｔｒｅｎｄｓ ｉｎ Ｎｅｕｒｏｓｃｉｅｎｃｅｓ, 1998, ｖｏｌ．２１， Ｎｏ．２, ｐ．７５−８０
Attorney, Agent or Firm:
Yoshikazu Tani (2 outside)