Title:
【発明の名称】神経細胞ニコチン性α7レセプタアゴニストとしてのベンジリデン-およびシンナミリデン-アナバセイン
Document Type and Number:
Japanese Patent JP2003524575
Kind Code:
A
Abstract:
This invention relates to compositions for benzylidene- and cinnamylidene-anabaseines and methods for using these compositions for treating conditions associated with defects or malfunctioning of nicotinic subtypes brain receptors. These compositions target the alpha7 receptor subtype with little or no activation of the alpha4beta2 or other receptor subtypes.
Inventors:
Chem, William Earl.
Van Helen, France
Zolte Wids, John A.
Borgs Lavada Campbell
Papuk, Roger
Day, Arthur El.
Faesen, Louis M Her
Van Helen, France
Zolte Wids, John A.
Borgs Lavada Campbell
Papuk, Roger
Day, Arthur El.
Faesen, Louis M Her
Application Number:
JP2000507667A
Publication Date:
August 19, 2003
Filing Date:
August 28, 1998
Export Citation:
Assignee:
University of Florida
International Classes:
A61K31/444; A61P9/10; A61P25/28; A61P25/34; A61P43/00; C07D211/82; C07D401/04; C07D405/14; (IPC1-7): C07D401/04; A61K31/444; A61P9/10; A61P25/28; A61P25/34; A61P43/00
Domestic Patent References:
| JPH08509458A | 1996-10-08 | |||
| JPH08242866A | 1996-09-24 |
Foreign References:
| WO1997030998A1 | 1997-08-28 | |||
| WO1996040211A1 | 1996-12-19 | |||
| WO1996006098A1 | 1996-02-29 |
Other References:
JPN6009018930, ＤＥ ＦＩＥＢＲＥ，Ｃ．Ｍ． ｅｔ ａｌ, "Ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ ａ ｓｅｒｉｅｓ ｏｆ ａｎａｂａｓｅｉｎｅ−ｄｅｒｉｖｅｄ ｃｏｍｐｏｕｎｄｓ ｒｅｖｅａｌｓ ｔｈａｔ ｔｈｅ ３−（４）−ｄｉｍｅｔｈｙｌａｍｉｎｏｃｉｎ", Ｍｏｌｅｃｕｌａｒ Ｐｈａｒｍａｃｏｌｏｇｙ, 1995, Ｖｏｌ．４７， Ｎｏ．１, ｐ．１６４−１７１
Attorney, Agent or Firm:
Shusaku Yamamoto