Title:
【発明の名称】治療用ペプチド
Document Type and Number:
Japanese Patent JP2003525040
Kind Code:
A
Abstract:
The invention provides peptides of about 9-12 amino acids having a sequence derived from the interferon binding site of the IFNAR1 chain of the Type 1-interferon (Type 1-IFN) receptor for use as a Type 1-IFN antagonist. In particular, the invention provides peptides having the 9 mer sequence FSSLKLNVY (SEQ ID no. 1) and analogues thereof for use as Type 1-IFN antagonists. Particularly preferred for this purpose is the peptide of SEQ ID no. 1 and analogues thereof including SEQ ID no. 1 having an additional asparagine residue (N) at the C-terminus and/or additional glutamic acid residue (E) at the N-terminus.
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Inventors:
Harles, nail james
Aid, Pierre
Aid, Pierre
Application Number:
JP2001561062A
Publication Date:
August 26, 2003
Filing Date:
January 25, 2001
Export Citation:
Assignee:
Pharma Pacific Proprietary Limited
International Classes:
A61K35/76; A61K38/00; A61K48/00; A61P3/10; A61P17/06; A61P19/02; A61P25/00; A61P37/02; A61P37/06; A61P43/00; C07K7/06; C07K7/08; C07K14/715; C12N15/09; (IPC1-7): C12N15/09; A61K35/76; A61K38/00; A61K48/00; A61P3/10; A61P17/06; A61P19/02; A61P25/00; A61P37/02; A61P37/06; A61P43/00; C07K7/06; C07K7/08
Other References:
JPN6010045925, Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ, 199302, １５０, ７０７−７１６
JPN6010045926, Ｅｕｒｏｐｉａｎ Ｃｙｔｏｋｉｎｅ Ｎｅｔｗｏｒｋ, 200012, １１, ５６０−５７３
JPN6010045927, Ｂｉｏｃｈｅｍｉｓｔｒｙ, 2004, ４３, １２４９８−１２５１２
JPN6010045926, Ｅｕｒｏｐｉａｎ Ｃｙｔｏｋｉｎｅ Ｎｅｔｗｏｒｋ, 200012, １１, ５６０−５７３
JPN6010045927, Ｂｉｏｃｈｅｍｉｓｔｒｙ, 2004, ４３, １２４９８−１２５１２
Attorney, Agent or Firm:
Akira Asamura (3 outside)