Title:
【発明の名称】スルホンアミド置換架橋ビシクロアルキル誘導体
Document Type and Number:
Japanese Patent JP2003528076
Kind Code:
A
Abstract:
A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease.
Inventors:
Belangier, Patrice Shyaruru
Collins, Ian The James
Han Nam, Johan Clair
Harrison, Tamothy
Lewis, Stephen Jiyoung
Madein, Andrew
McIver, Edward Jills
Alain Jiyoung, Nadein
Nedo Beryl, Yogyif Yogyoji
Sheerman, Mark Stephen
Smith, Adrian Leonard
Sparry, Timothy Theason
Stephenson, Graham Irvine
Taylor, Martin Lichyard
Collins, Ian The James
Han Nam, Johan Clair
Harrison, Tamothy
Lewis, Stephen Jiyoung
Madein, Andrew
McIver, Edward Jills
Alain Jiyoung, Nadein
Nedo Beryl, Yogyif Yogyoji
Sheerman, Mark Stephen
Smith, Adrian Leonard
Sparry, Timothy Theason
Stephenson, Graham Irvine
Taylor, Martin Lichyard
Application Number:
JP2001568889A
Publication Date:
September 24, 2003
Filing Date:
March 15, 2001
Export Citation:
Assignee:
Merck Sharp End Dome Limited
Merck Frost Canada and Company
Merck Frost Canada and Company
International Classes:
A61K31/18; A61K31/277; A61K31/343; A61K31/357; A61K31/381; A61K31/40; A61K31/407; A61K31/4164; A61K31/4196; A61K31/4245; A61K31/425; A61K31/438; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4436; A61K31/4439; A61K31/4535; A61K31/47; A61K31/495; A61K31/496; A61K31/4985; A61K31/5377; A61K31/55; A61P25/28; A61P43/00; C07C211/42; C07C251/44; C07C311/07; C07C311/09; C07C311/11; C07C311/14; C07C311/20; C07C311/24; C07C311/29; C07C323/67; C07D207/06; C07D207/36; C07D211/14; C07D211/18; C07D213/30; C07D213/38; C07D213/71; C07D213/81; C07D215/12; C07D223/32; C07D233/84; C07D249/08; C07D271/107; C07D275/02; C07D277/20; C07D277/36; C07D277/42; C07D277/54; C07D285/14; C07D285/16; C07D295/088; C07D295/092; C07D295/135; C07D295/18; C07D295/26; C07D307/64; C07D307/81; C07D319/18; C07D333/20; C07D333/34; C07D409/12; C07D413/12; C07D413/14; C07D417/04; C07D417/06; C07D417/12; C07D417/14; C07D487/04; C07D487/08; C07D491/08; C07D491/10; C07D491/107; C07D513/10; C07D521/00; C07D271/10; (IPC1-7): A61K31/18; A61K31/277; A61K31/343; A61K31/357; A61K31/381; A61K31/407; A61K31/4164; A61K31/4196; A61K31/4245; A61K31/425; A61K31/438; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4436; A61K31/4439; A61K31/4535; A61K31/47; A61K31/495; A61K31/496; A61K31/4985; A61K31/5377; A61K31/55; A61P25/28; A61P43/00; C07C311/07; C07C311/11; C07C311/14; C07C311/20; C07C311/29; C07C323/67; C07D207/06; C07D207/36; C07D213/30; C07D213/38; C07D213/71; C07D213/81; C07D223/32; C07D233/84; C07D249/08; C07D275/03; C07D277/36; C07D277/54; C07D295/18; C07D307/64; C07D307/81; C07D319/18; C07D333/20; C07D333/34; C07D409/12; C07D413/12; C07D413/14; C07D487/04; C07D491/08; C07D491/107
Domestic Patent References:
| JPH11322705A | 1999-11-24 | |||
| JPH02180862A | 1990-07-13 | |||
| JPS63139161A | 1988-06-10 |
Foreign References:
| US5703129A | 1997-12-30 | |||
| WO2000046189A1 | 2000-08-10 | |||
| WO1997000853A1 | 1997-01-09 | |||
| US3715362A | 1973-02-06 | |||
| US3406184A | 1968-10-15 | |||
| US4479901A | 1984-10-30 | |||
| US3917688A | 1975-11-04 |
Attorney, Agent or Firm:
Yoshio Kawaguchi (4 outside)