Title:
【発明の名称】新規な抗不整脈性ペプチド
Document Type and Number:
Japanese Patent JP2003528826
Kind Code:
A
Abstract:
The present invention relates to a compound having the general formula (I) where the dashed line indicates that formula (I) is optionally cyclic, and the bonds shown represent covalent bonds; and wherein A represents a chemical moiety having an amino group (radical) and a carboxy group that forms part of the peptide bond connecting A to X and B; B represents a chemical moiety having an amino group (radical) and a carboxy group that forms part of the peptide bond connecting B to A and Y; X represents a peptide sequence of from 1 to 3 amino acid residues which independently may be an L or D form when Y represents a C-terminal peptide sequence of from 2 to 5 amino acid residues which may independently be L- or D-forms; or X represents an N-terminal modification of the group A-B when Y represents a C-terminal peptide sequence of from 2 to 5 amino acid residues which may independently be L- or D-forms; or X represents a peptide sequence of from 2 to 5 amino acid residues which may independently be L- or D-forms when Y represents a C-terminal peptide sequence of from 1 to 3 amino acid residues which independently may be an L or D form; and when formula (I) represents a linear peptide X is optionally chemically modified at its N-terminal, and L is an optional linking group comprising from 0 to 8 backbone atoms; and a mirror image or a retro analogue of formula (I), or a derivative of formula (I) which is a pharmaceutically acceptable salt, and alkyl, aryl or aralkyl ester, an amide, a mono or disubstituted amide where the substituent is an alkyl, an aryl or an aralkyl, a hydrazide, or an alcohol.
Inventors:
Biarun du Ralsen
Jorgen Soberg Petersen
Eddie Mayr
Anne Louis Jorbaix
Niklas Ryo Jorgensen
Molten Shark Nielsen
Nils-Henrik Holstein-Lasslaw
James B. Martins
Jorgen Soberg Petersen
Eddie Mayr
Anne Louis Jorbaix
Niklas Ryo Jorgensen
Molten Shark Nielsen
Nils-Henrik Holstein-Lasslaw
James B. Martins
Application Number:
JP2001562556A
Publication Date:
September 30, 2003
Filing Date:
February 22, 2001
Export Citation:
Assignee:
Zealand Pharma A/S
International Classes:
A61K38/00; A61P1/00; A61P1/04; A61P3/00; A61P3/08; A61P3/10; A61P7/02; A61P9/00; A61P9/06; A61P9/12; A61P15/08; A61P17/02; A61P19/02; A61P19/10; A61P25/18; A61P25/22; A61P25/28; A61P27/02; A61P27/12; A61P27/16; A61P35/00; A61P43/00; C07K5/06; C07K5/062; C07K5/078; C07K5/08; C07K5/083; C07K5/097; A61K9/20; C07K5/10; C07K5/103; C07K7/00; C07K7/06; C07K7/64; (IPC1-7): C07K7/00; A61K9/20; A61K38/00; A61P1/00; A61P1/04; A61P3/00; A61P3/08; A61P3/10; A61P7/02; A61P9/00; A61P9/06; A61P9/12; A61P15/08; A61P17/02; A61P19/02; A61P19/10; A61P25/18; A61P25/22; A61P25/28; A61P27/02; A61P27/12; A61P27/16; A61P35/00; A61P43/00; C07K5/06; C07K5/08; C07K5/10
Attorney, Agent or Firm:
Masatake Shiga (7 outside)