Title:
【発明の名称】鎮痛剤としてのベンゾスベロニルピペリジン化合物
Document Type and Number:
Japanese Patent JP2003531896
Kind Code:
A
Abstract:
Compounds of formula (I) or a derivative thereof, wherein; R is C1-6alkyl, C3-7cycloalkyl, C1-6alkoxy, hydroxy, halo, C1-6alkenyl, C1-6alkynyl, amino, C1-6alkylamino, di(C1-6alkyl)amino, hydroxyC1-6alkyl, C1-6alkoxyC1-6alkyl, aminoC1-6alkyl, (C1-6alkyl)aminoC1-6alkyl, di(C1-6alkyl)aminoC1-6alkyl; R1 is hydrogen or R; R2 is hydroxy, C1-6alkoxy, amino, C1-6alkylamino, di(C1-6alkyl)amino; R3 is hydrogen or C1-6alkyl; R4 and R5 are each independently selected from the list consisting of perhaloC1-6alkyl, hydrogen, halo, C1-6alkyl, C1-6alkoxy, hydroxy, amino, C1-6alkylamino, di(C1-6alkyl)amino, hydroxyC1-6alkyl, C1-6alkoxyC1-6alkyl, aminoC1-6alkyl, (C1-6alkyl)aminoC1-6alkyl, di(C1-6alkyl)aminoC1-6alkyl, aryl, and COX wherein X may be hydroxy, C1-6alkoxy, C1-6alkyl, amino, C1-6alkylamino, or di(C1-6alkyl)amino; with the proviso that, when R3 is hydrogen, then R4 and R5 are not both hydrogen; and wherein any alkyl group or the alkyl moiety of any group containing such a moiety may be substituted one or more times by halo; are ligands of the ORL-1 receptor and are useful in therapy.
Inventors:
Daniella Barrocco
Giorgio Chinarella
Giuseppe Giardina
Mario gruni
Silvano ronzoni
Giorgio Chinarella
Giuseppe Giardina
Mario gruni
Silvano ronzoni
Application Number:
JP2001580883A
Publication Date:
October 28, 2003
Filing Date:
May 01, 2001
Export Citation:
Assignee:
GlaxoSmithKline S.p.A.
International Classes:
A61K31/451; A61P1/00; A61P1/16; A61P3/04; A61P7/04; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P11/14; A61P13/00; A61P15/00; A61P19/02; A61P25/00; A61P25/02; A61P25/04; A61P25/16; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P43/00; C07D211/14; C07D211/18; C07D211/22; (IPC1-7): C07D211/22; A61K31/451; A61P1/00; A61P1/16; A61P3/04; A61P7/04; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P11/14; A61P13/00; A61P15/00; A61P19/02; A61P25/00; A61P25/02; A61P25/04; A61P25/16; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P43/00
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)