Title:
【発明の名称】癌細胞の増殖を阻害しそのアポトーシスを誘導する方法
Document Type and Number:
Japanese Patent JP2003532675
Kind Code:
A
Abstract:
Disclosed are methods of decreasing proliferation of adenocarcinoma cancer cells, or of inducing apoptosis of adenocarcinoma cancer cells, or of inducing differentiation of adenocarcinoma cancer cells into non-cancerous cells. One such method includes contacting the adenocarcinoma cancer cells with a compound under conditions effective for the compound to inhibit binding of leukotriene B4 to leukotriene B4 receptor. In another such method, the method includes contacting the adenocarcinoma cancer cells with 2-(2-propyl-3-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenoxy)benzoic acid or a pharmaceutically acceptable salt, solvate, or congener thereof. Also disclosed are methods of treating adenocarcinomas in a subject. One method includes administering to the subject an amount of a compound effective to inhibit binding of leukotriene B4 to leukotriene B4 receptor. Another method includes administering 2-(2-propyl-3-(3-(2-ethyl-4-(4-fluoropheyl)-5-hydroxyphenoxy)propoxy)phenoxy)benzoic acid or a pharmaceutically acceptable salt, solvate, or congener thereof, to the subject.
Inventors:
Adrian, Thomas, Yi.
Application Number:
JP2001581820A
Publication Date:
November 05, 2003
Filing Date:
May 08, 2001
Export Citation:
Assignee:
Clayton University
International Classes:
A61K45/00; A61K31/00; A61K31/192; A61K31/194; A61K31/352; A61K31/41; A61P35/00; A61P43/00; (IPC1-7): A61K45/00; A61K31/192; A61K31/194; A61K31/352; A61K31/41; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Ken Takahashi