Title:
【発明の名称】キメラペプチド免疫原
Document Type and Number:
Japanese Patent JP2003532740
Kind Code:
A
Abstract:
Chimeric peptide epitopes can serve as effective immunogens against hormones and other small peptides or proteins. Thus, immunogenic peptides are selected from promiscuous Th epitopes and synthesized together with self antigenic peptide sequences fused with or without end to end spacer peptide interconnections. A peptide sequence which may be of the gonadotropin releasing hormone is linked with an immunogenic peptide sequence selected from a promiscuous Th-epitope of measles virus protein F, tetanus toxoid, or malaria protein CSP. Compositions of the chimeric immunogen are found effective in eliciting high and specific anti-GnRH antibody titers.
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Inventors:
Grimus, Stefan
Maikeli, Dub
Stevens, Vernon, Sea.
Maikeli, Dub
Stevens, Vernon, Sea.
Application Number:
JP2001582362A
Publication Date:
November 05, 2003
Filing Date:
May 04, 2001
Export Citation:
Assignee:
Afton Corporation
International Classes:
A61K39/00; A61K39/395; A61P5/00; A61P5/02; A61P13/08; A61P35/00; A61P37/02; A61P43/00; C07K7/23; C07K14/575; C07K19/00; (IPC1-7): C07K14/575; A61K39/00; A61P5/00; A61P5/02; A61P13/08; A61P35/00; A61P37/02; A61P43/00; C07K19/00
Attorney, Agent or Firm:
Masayoshi Misawa