Title:
【発明の名称】神経損傷の修復
Document Type and Number:
Japanese Patent JP2003532742
Kind Code:
A
Abstract:
The invention provides a method of treating nerve damage involving administering to the damaged nerve an effective non-toxic amount of an MGF (mechano-growth factor) Insulin-like Growth Factor I (IGF-I) isoform which includes amino acid sequences encoded by nucleic acid sequences of IGF-I exons 4, 5 and 6 in the reading frame of MGF and having the ability to reduce motoneurone loss by 20% or greater in response to nerve avulsion.
Inventors:
Golds pink, geoffrey
Terengi, Georgeo
Terengi, Georgeo
Application Number:
JP2001582380A
Publication Date:
November 05, 2003
Filing Date:
May 10, 2001
Export Citation:
Assignee:
University College London
East Grinstead Medical Research Trust
East Grinstead Medical Research Trust
International Classes:
C12N15/09; A61K38/22; A61K38/30; A61K45/00; A61K48/00; A61P21/00; A61P25/00; C07K14/65; A61K38/00; (IPC1-7): A61K38/22; A61K45/00; A61K48/00; A61P21/00; A61P25/00; C12N15/09
Domestic Patent References:
| JP2003520784A | 2003-07-08 |
Foreign References:
| EP0308386A1 | 1989-03-22 | |||
| WO1997033997A1 | 1997-09-18 |
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)