Title:
(R)-2-アルキル-3-フェニルプロピオン酸の調製
Document Type and Number:
Japanese Patent JP2004502663
Kind Code:
A
Abstract:
Compounds of formula (I), wherein R1 and R2 are, independently of one another, H, C1-C6alkyl, C1-C6halogenalkyl, C1-C6alkoxy, C1-C6alkoxy-C1-C6alkyl, or C1-C6alkoxy-C1l-C6alkyloxy, and R3 is C1-C6alkyl, are obtainable in high yields by stereoselective addition of R3-substituted propionic acid esters to R1- and R2-substituted benzaldehydes of formula R-CHO to form corresponding 3-R-3-hydroxy-2-R3-propionic acid esters, conversion of the OH group to a leavaing group, subsequent regioselective elimination to form 3-R-2-R3-propenic acid esters, and their hydrolysis to form corresponding propenic carboxylic acids and their enantioselective hydrogenation, wherein R is (a).
Inventors:
Herolt, peter
Stutz, Stephan
Felix, Spintorer
Sturm, Thomas
Weissensteiner, Walther
Stutz, Stephan
Felix, Spintorer
Sturm, Thomas
Weissensteiner, Walther
Application Number:
JP2002507758A
Publication Date:
January 29, 2004
Filing Date:
June 26, 2001
Export Citation:
Assignee:
SPEEDEL PHARMA AG
International Classes:
B01J31/24; C07B53/00; C07B61/00; C07C51/36; C07C59/64; C07C59/66; C07C62/34; (IPC1-7): C07C51/36; B01J31/24; C07C59/64; C07C62/34
Domestic Patent References:
| JPH0827079A | 1996-01-30 | |||
| JPH09309826A | 1997-12-02 | |||
| JP2003519135A | 2003-06-17 |
Foreign References:
| US4307232A | 1981-12-22 |
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda