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Title:
免疫強化並びに癌、感染および躁鬱病の治療のための置換ベンズアミド
Document Type and Number:
Japanese Patent JP2004502668
Kind Code:
A
Abstract:
This invention relates to the use of compounds of general formula (I) wherein, R is selected from methyl, ethyl, n-propyl, iso-propyl, c-propyl, n-butyl, sec.-butyl, iso-butyl, tert.-butyl, c-butyl, n-pentyl, sec.-pentyl, iso-pentyl, tert.pentyl, neo-pentyl, c-pentyl, c-hexyl and c-heptyl; RNa and RNb are the same or different and selected from hydrogen, methyl and ethyl; R2, R3, R5 and R6 are independently selected from hydrogen, methyl, methoxy, thiomethyl, hydroxy, fluoro, chloro, bromo, trifluoromethyl, phenyl and benzyl; n is 1, 2 or 3; R' and R'' are the same or different and selected from methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec.-butyl, and iso-butyl or R' and R'' together form a saturated heterocyclic ring of 5-7 atoms is 1, 2, 3; and pharmaceutically acceptable salts, hydrates and solvates thereof; for the preparation of a medicament for stimulation of transcription factor AP (activator protein)-1; compositions comprising the compounds of formula (I). The invention also comprises the compounds of general formula (I) with the exclusion of compounds wherein R, R' and R'' simultaneously are methyl. The compounds are useful for the treatment of cancer, infection and manic-depressive illness.

Inventors:
ビョーク アンダース
ヘドルンド グナー
リーダーソン トーマス
Application Number:
JP2002507768A
Publication Date:
January 29, 2004
Filing Date:
July 03, 2001
Export Citation:
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Assignee:
アクティブ バイオテック エイビー
International Classes:
C07D295/12; A61K31/166; A61K31/167; A61K31/495; A61K31/5375; A61P19/02; A61P25/18; A61P25/24; A61P29/00; A61P31/00; A61P31/18; A61P35/00; A61P37/02; A61P37/04; A61P43/00; C07C237/42; C07C237/44; C07D295/13; (IPC1-7): C07C237/44; A61K31/167; A61K31/495; A61K31/5375; A61P19/02; A61P25/18; A61P25/24; A61P29/00; A61P31/00; A61P31/18; A61P35/00; A61P37/02; A61P43/00; C07D295/12
Domestic Patent References:
JPS4961134A1974-06-13
JPS59164779A1984-09-17
JPS63313757A1988-12-21
JPH05221950A1993-08-31
JPH10279548A1998-10-20
JPH10504324A1998-04-28
JPH1180107A1999-03-26
JP2001151742A2001-06-05
Foreign References:
WO1999063987A11999-12-16
US4568685A1986-02-04
BE620543A
GB1174956B
GB896720B
GB1098598B
US3219528A1965-11-23
Attorney, Agent or Firm:
林 孝吉