Title:
生物活性被覆組成物と方法
Document Type and Number:
Japanese Patent JP2004505124
Kind Code:
A
Abstract:
The present invention provides an anti-thrombogenic and cellular-adhesion coating composition for blood-contacting surfaces. The coating comprises a covalent complex of from 1 to 30 hydrophobic silyl moieties of Formula I:wherein R1 is an C1-18 alkyl or C6-32 aryl group, each R2 is independently selected from the group consisting of C1-18 alkyl and C6-32 aryl, R3 is N or O, n is a number from 1 to 10, directly bound to a heparin molecule via covalent bonding, with an adhesive molecule directly bound to the heparin molecule. In one embodiment, the coating comprises benzyl-(1,2 dimethyl)disilyl heparin, wherein an adhesive molecule, such as fibronectin, is bound to the heparin.
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Inventors:
Zamora, Paul, Oh.
Osaki, Shigemasa
Tsang, Ray
Osaki, Shigemasa
Tsang, Ray
Application Number:
JP2002515949A
Publication Date:
February 19, 2004
Filing Date:
July 31, 2001
Export Citation:
Assignee:
Biosurface Engineering Technologies, Inc.
International Classes:
A61L33/10; A61L27/28; A61L31/08; A61L33/00; A61L33/08; C08B37/00; C08B37/10; C08G77/60; C09D105/08; C09D105/10; (IPC1-7): C08B37/10; A61L33/10
Attorney, Agent or Firm:
Takenori Hiroe
Kenichi Uno
Kenichi Uno