Title:
リバビリンを含むワクチンおよびその使用方法
Document Type and Number:
Japanese Patent JP2004506018
Kind Code:
A
Abstract:
Compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans are disclosed. More particularly, vaccine compositions comprising ribavirin and an antigen, preferably an antigen that has an epitope present in Hepatitis C virus (HCV), are disclosed for use in treating and preventing disease, preferably HCV infection.
Inventors:
Mattberg, Salberg
Furtgren, Catalina
Furtgren, Catalina
Application Number:
JP2002518994A
Publication Date:
February 26, 2004
Filing Date:
August 15, 2001
Export Citation:
Assignee:
Tripep Acti Boraget
International Classes:
C12N15/09; A61K31/7052; A61K38/00; A61K39/00; A61K39/29; A61K39/39; A61K48/00; A61P31/14; A61P37/04; C07K14/18; C12N7/00; C12N7/01; C12N15/40; (IPC1-7): A61K39/39; A61K31/7052; A61K38/00; A61K39/00; A61K39/29; A61K48/00; A61P31/14
Domestic Patent References:
| JPH0581600B1 | 1993-11-15 |
Foreign References:
| WO1997026883A1 | 1997-07-31 | |||
| WO1997026883A1 | 1997-07-31 |
Other References:
JPN6011025771; ＺＨＡＮＧ，Ｚ．Ｘ． ｅｔ ａｌ: 'Ｉｎｔｅｒｆｅｒｏｎ-ａｌｐｈａ ｔｒｅａｔｍｅｎｔ ｉｎｄｕｃｅｓ ｄｅｌａｙｅｄ ＣＤ４ ｐｒｏｌｉｆｅｒａｔｉｖｅ ｒｅｓｐｏｎｓｅｓ ｔｏ ｔｈｅ ｈｅｐａｔｉｔｉｓ Ｃ ｖｉｒｕｓ ｎｏｎｓ' Ｊ Ｉｎｆｅｃｔ Ｄｉｓ Ｖｏｌ．１７５， Ｎｏ．６, 1997, ｐ．１２９４-３０１
JPN6011025760; ＨＵＬＴＧＲＥＮ，Ｃ． ｅｔ ａｌ: 'Ｔｈｅ ａｎｔｉｖｉｒａｌ ｃｏｍｐｏｕｎｄ ｒｉｂａｖｉｒｉｎ ｍｏｄｕｌａｔｅｓ ｔｈｅ Ｔ ｈｅｌｐｅｒ （Ｔｈ） １／Ｔｈ２ ｓｕｂｓｅｔ ｂａｌａｎｃｅ ｉｎ ｈｅｐａｔｉｔｉｓ Ｂ ａｎｄ' Ｊ Ｇｅｎ Ｖｉｒｏｌ Ｖｏｌ．７９ ， Ｎｏ． Ｐｔ １０, 1998, ｐ．２３８１-９１
JPN5003006822; ＣＨＩＡＮＧ Ｂ Ｌ: 'Ｅｎｈａｎｃｅｍｅｎｔ ｏｆ ｈｅｐａｔｉｔｉｓ ｃ ｖｉｒｕｓ ｃｏｒｅ ａｎｔｉｇｅｎ-ｓｐｅｃｉｆｉｃ ｔｙｐｅ １ Ｔ ｈｅｌｐｅｒ ｃｅｌｌ ｒｅｓｐｏｎｓｅ ｂｙ ｒｉｂａｖｉｒｉｎ ｃｏ' ＦＡＳＥＢ ＪＯＵＲＮＡＬ Ｖ１４Ｎ６, 20000420, ＰＡ９４９
JPN6011025764; 矢萩則夫ら: 'Ｃ型肝炎の診断と病態解析 ＨＣＶ抗体検査法と病態解析' 臨床病理 Ｖｏｌ．３９， Ｎｏ．６, 1991, ５７８-８５
JPN6011025767; ＡＢＲＩＧＮＡＮＩ，Ｓ． ｅｔ ａｌ: 'Ｐｅｒｓｐｅｃｔｉｖｅｓ ｆｏｒ ａ ｖａｃｃｉｎｅ ａｇａｉｎｓｔ ｈｅｐａｔｉｔｉｓ Ｃ ｖｉｒｕｓ' Ｊ Ｈｅｐａｔｏｌ Ｖｏｌ．３１ Ｓｕｐｐｌ １, 1999, ｐ．２５９-６３
JPN6011025771; ＺＨＡＮＧ，Ｚ．Ｘ． ｅｔ ａｌ: 'Ｉｎｔｅｒｆｅｒｏｎ-ａｌｐｈａ ｔｒｅａｔｍｅｎｔ ｉｎｄｕｃｅｓ ｄｅｌａｙｅｄ ＣＤ４ ｐｒｏｌｉｆｅｒａｔｉｖｅ ｒｅｓｐｏｎｓｅｓ ｔｏ ｔｈｅ ｈｅｐａｔｉｔｉｓ Ｃ ｖｉｒｕｓ ｎｏｎｓ' Ｊ Ｉｎｆｅｃｔ Ｄｉｓ Ｖｏｌ．１７５， Ｎｏ．６, 1997, ｐ．１２９４-３０１
JPN6011025760; ＨＵＬＴＧＲＥＮ，Ｃ． ｅｔ ａｌ: 'Ｔｈｅ ａｎｔｉｖｉｒａｌ ｃｏｍｐｏｕｎｄ ｒｉｂａｖｉｒｉｎ ｍｏｄｕｌａｔｅｓ ｔｈｅ Ｔ ｈｅｌｐｅｒ （Ｔｈ） １／Ｔｈ２ ｓｕｂｓｅｔ ｂａｌａｎｃｅ ｉｎ ｈｅｐａｔｉｔｉｓ Ｂ ａｎｄ' Ｊ Ｇｅｎ Ｖｉｒｏｌ Ｖｏｌ．７９ ， Ｎｏ． Ｐｔ １０, 1998, ｐ．２３８１-９１
JPN5003006822; ＣＨＩＡＮＧ Ｂ Ｌ: 'Ｅｎｈａｎｃｅｍｅｎｔ ｏｆ ｈｅｐａｔｉｔｉｓ ｃ ｖｉｒｕｓ ｃｏｒｅ ａｎｔｉｇｅｎ-ｓｐｅｃｉｆｉｃ ｔｙｐｅ １ Ｔ ｈｅｌｐｅｒ ｃｅｌｌ ｒｅｓｐｏｎｓｅ ｂｙ ｒｉｂａｖｉｒｉｎ ｃｏ' ＦＡＳＥＢ ＪＯＵＲＮＡＬ Ｖ１４Ｎ６, 20000420, ＰＡ９４９
JPN6011025764; 矢萩則夫ら: 'Ｃ型肝炎の診断と病態解析 ＨＣＶ抗体検査法と病態解析' 臨床病理 Ｖｏｌ．３９， Ｎｏ．６, 1991, ５７８-８５
JPN6011025767; ＡＢＲＩＧＮＡＮＩ，Ｓ． ｅｔ ａｌ: 'Ｐｅｒｓｐｅｃｔｉｖｅｓ ｆｏｒ ａ ｖａｃｃｉｎｅ ａｇａｉｎｓｔ ｈｅｐａｔｉｔｉｓ Ｃ ｖｉｒｕｓ' Ｊ Ｈｅｐａｔｏｌ Ｖｏｌ．３１ Ｓｕｐｐｌ １, 1999, ｐ．２５９-６３
JPN6011025771; ＺＨＡＮＧ，Ｚ．Ｘ． ｅｔ ａｌ: 'Ｉｎｔｅｒｆｅｒｏｎ-ａｌｐｈａ ｔｒｅａｔｍｅｎｔ ｉｎｄｕｃｅｓ ｄｅｌａｙｅｄ ＣＤ４ ｐｒｏｌｉｆｅｒａｔｉｖｅ ｒｅｓｐｏｎｓｅｓ ｔｏ ｔｈｅ ｈｅｐａｔｉｔｉｓ Ｃ ｖｉｒｕｓ ｎｏｎｓ' Ｊ Ｉｎｆｅｃｔ Ｄｉｓ Ｖｏｌ．１７５， Ｎｏ．６, 1997, ｐ．１２９４-３０１
Attorney, Agent or Firm:
Tsutomu Toyama
Hidemi Matsukura
Yoshiyuki Kawaguchi
Yutaka Nagata
Hidemi Matsukura
Yoshiyuki Kawaguchi
Yutaka Nagata