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Title:
イソオキサゾールおよびERKのインヒビターとしてのその使用
Document Type and Number:
Japanese Patent JP2004509119
Kind Code:
A
Abstract:
Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula: where A, B, R1, R2, T and Ht are described in the specification. The compounds are useful for treating diseases in mammals that are alleviated by a protein, kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.

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Inventors:
Hale, Michael
Janeka, James
Marthais, Francois
Khao, Jin Long
Marshall, robert
Application Number:
JP2002526863A
Publication Date:
March 25, 2004
Filing Date:
September 14, 2001
Export Citation:
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Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
A61K31/42; A61K31/433; A61K31/4439; A61K31/454; A61K31/4725; A61K31/496; A61K31/5377; A61K31/551; A61K45/00; A61P1/00; A61P1/02; A61P1/16; A61P1/18; A61P3/10; A61P5/00; A61P7/02; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P11/00; A61P11/06; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P19/04; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/20; A61P25/28; A61P29/00; A61P31/00; A61P31/12; A61P35/00; A61P35/02; A61P37/02; A61P37/08; A61P43/00; C07D413/04; C07D413/14; C07D417/14; (IPC1-7): C07D413/04; A61K31/42; A61K31/433; A61K31/4439; A61K31/454; A61K31/4725; A61K31/496; A61K31/5377; A61K31/551; A61K45/00; A61P1/00; A61P1/02; A61P1/16; A61P1/18; A61P3/10; A61P5/00; A61P7/02; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P11/00; A61P11/06; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P19/04; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/20; A61P25/28; A61P29/00; A61P31/00; A61P31/12; A61P35/00; A61P35/02; A61P37/02; A61P37/08; A61P43/00; C07D413/14; C07D417/14
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita



 
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