Title:
HDACインヒビターとしてのアミド結合を含むカルバミン酸化合物
Document Type and Number:
Japanese Patent JP2004509941
Kind Code:
A
Abstract:
This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula:
wherein: A is an aryl group; Q 1 is an aryl leader group having a backbone of at least 2 carbon atoms; J is an amide linkage selected from: -NR 1 (=O)- and -C(=O)NR 1 -; R 1 is an amido substituent; and, Q 2 is an acid leader group; and pharmaceutically acceptable salts, solvates, amides, esters, and ethers thereof, for use in the treatment of a fibroproliferative disorder; liver fibrosis; smooth muscle proliferative disorder; atherosclerosis; restenosis; a neurodegenative disease; Alzheimer's; Parkinson's; Huntington's chorea; amyotropic lateral sclerosis; spino-cerebellar degeneration; an inflammatory disease; osteoarthritis; rheumatoid arthritis; a diseases involving angiogenesis; diabetic retinopathy; a haematopoietic disorder; anaemia; sickle cell anaemia; thalassaeimia; a fungal infection; a parasitic infection; trypanosomiasis; helminthiasis; a protozoal infection; a bacterial infection; a viral infection; a condition treatable by immune modulation; multiple sclerosis; autoimmune diabetes; lupus; atopic dermatitis; an allergy; asthma; allergic rhinitis; or inflammatory bowel disease.
Inventors:
Watkins, Clara, Jay.
Romero-Martin, Maria-Rosario
Moore, Kathryn, Gee.
Richie, james
Fin, Paul, W.
Calvinche, Iwals
Rosa, Ainers
Starchenkov, Igor
Dikovska, Clara
Bocardel, Rasma, Melita
Gallito, Villa
Verona, Maxim
Andrianov, Victor
Loria, diana
Semeni Kina, Valentina
Amorins, Andris
Harris, Sea., John
Duffy, James, E., S.
Romero-Martin, Maria-Rosario
Moore, Kathryn, Gee.
Richie, james
Fin, Paul, W.
Calvinche, Iwals
Rosa, Ainers
Starchenkov, Igor
Dikovska, Clara
Bocardel, Rasma, Melita
Gallito, Villa
Verona, Maxim
Andrianov, Victor
Loria, diana
Semeni Kina, Valentina
Amorins, Andris
Harris, Sea., John
Duffy, James, E., S.
Application Number:
JP2002531082A
Publication Date:
April 02, 2004
Filing Date:
September 27, 2001
Export Citation:
Assignee:
Pro Refix Limited
International Classes:
A61K31/16; A61K31/165; A61K31/166; A61K31/167; A61K31/195; A61K31/198; A61K31/216; A61K31/277; A61K31/341; A61K31/343; A61K31/38; A61K31/381; A61K31/40; A61K31/4015; A61K31/4045; A61K31/405; A61K31/4184; A61K31/4245; A61K31/426; A61K31/4402; A61K31/4409; A61P17/06; A61P31/20; A61P35/00; A61P43/00; C07C233/49; C07C233/83; C07C235/34; C07C237/36; C07C255/57; C07C259/06; C07C259/08; C07D207/337; C07D207/40; C07D207/404; C07D209/14; C07D209/16; C07D209/18; C07D209/22; C07D213/06; C07D213/55; C07D213/56; C07D235/14; C07D235/24; C07D271/06; C07D271/08; C07D307/34; C07D307/54; C07D307/68; C07D317/60; C07D333/24; C07D333/60; C07D333/68; C07D403/12; C07D207/32; C07D235/10; (IPC1-7): C07C259/06; A61K31/165; A61K31/166; A61K31/167; A61K31/198; A61K31/216; A61K31/277; A61K31/341; A61K31/343; A61K31/381; A61K31/40; A61K31/4015; A61K31/4045; A61K31/405; A61K31/4184; A61K31/4245; A61K31/4402; A61K31/4409; A61P17/06; A61P35/00; A61P43/00; C07C259/08; C07D207/337; C07D207/40; C07D209/14; C07D209/22; C07D213/56; C07D235/24; C07D271/08; C07D307/54; C07D307/68; C07D317/60; C07D333/24; C07D333/68; C07D403/12
Domestic Patent References:
| JP2000510472A | 2000-08-15 |
Foreign References:
| WO2000044709A2 | 2000-08-03 | |||
| WO1998026773A1 | 1998-06-25 | |||
| WO2000044713A1 | 2000-08-03 | |||
| WO1998015525A1 | 1998-04-16 | |||
| WO1999019296A1 | 1999-04-22 | |||
| WO1993012075A1 | 1993-06-24 |
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Ai Fujii
Satoshi Fujita
Ai Fujii