Title:
免疫免除された抗原に対する細胞性免疫の検出および調整のための方法および薬剤
Document Type and Number:
Japanese Patent JP2004510950
Kind Code:
A
Abstract:
Recognition of the role of a cellular immune response to immune-privileged antigens in the etiology of paraneoplastic syndromes and tumor immunity has provided diagnostic and therapeutic methods for the detection of paraneoplastic antigen-specific cells, enhancing tumor immunity by increasing the population of cytotoxic T lymphocytes (CTLs), and suppressing cellular immunity to treat the paraneoplastic syndrome. Methods for the detection of memory and cytotoxic T lymphocytes are provided which utilize immune-privileged antigens or their peptides. Enhanced CTL production is provided by stimulating antigen presenting cells in vitro with immune-privileged antigen, with and without further exposure to T lymphocytes, prior to reintroduction of either the antigen-presenting cells and/or the T lymphocytes into the patient. Suppression of the cellular response to non-tumor cells expressing the immune-privileged antigen is provided by using agents with suppress; anti-cytokine therapy is also provided to limit cell surface expression of paraneoplastic antigens by non-tumor cells. Compositions comprising immune-privileged antigen peptides useful for diagnostic methods and therapeutic treatments are also described.
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Inventors:
Darnell Robert Bee.
Albert Matthew El.
Bird Wedge Nina
Albert Matthew El.
Bird Wedge Nina
Application Number:
JP2000557146A
Publication Date:
April 08, 2004
Filing Date:
June 30, 1999
Export Citation:
Assignee:
THE ROCKEFELLER UNIVERSITY
International Classes:
G01N33/53; A61K35/14; A61K39/00; A61K45/00; A61P25/00; A61P35/00; A61P37/04; C07K14/47; G01N33/50; G01N33/564; G01N33/569; G01N33/574; (IPC1-7): G01N33/53; A61K35/14; A61K39/00; A61K45/00; A61P25/00; A61P35/00; A61P37/04; G01N33/574
Attorney, Agent or Firm:
Masago Onishi