Title:
メムノペプチド、その製造方法および使用
Document Type and Number:
Japanese Patent JP2004512257
Kind Code:
A
Abstract:
Isoindole derivatives (I) are new. Isoindole derivatives of formula (I) and their salts are new: R1, R2 = (a) H and the other is OH or 1-4C alkoxy; or (b) both groups are H; or (c) R1+R2 together form =O; R3, R4 = (a) H and the other is OH or 1-4C alkoxy; or (b) both groups are H, or (c) R3+R4 together form =O; R8 = H, OH, 1-4C alkyl or 1-4C alkoxy; R6 = a group of formula (i) or (ii); R9, R10 = H or a glycosidically bound sugar; R5 = a bond to the C9 position of (i) When R6 = (i) or H; and R7 = H or a bond to the C9 position of (i) when R6 =(i); or R5, R7 = H; A = one or more amino acids, where the N atom in the isoindole ring is identical to the N-terminal amino acid nitrogen; and n = 1-12. Provided that A is not Glu when n = 1, R1+R2 together form =O, R3, R4, R7-R9 = H, R6 = (i) and R5 is a bond to C9 on (i). An Independent claim is included for preparation of (I).
Inventors:
Larslow Fertesh
Herbert Kogler
Astrito Marx
Matthias Seal
Herbert Kogler
Astrito Marx
Matthias Seal
Application Number:
JP2001564208A
Publication Date:
April 22, 2004
Filing Date:
February 15, 2001
Export Citation:
Assignee:
Aventis Pharma Deutsche Land Gesellschaft Mitt Beschlenktel Haftung
International Classes:
C12P21/02; A61K38/00; A61K38/08; A61P3/10; A61P9/00; A61P9/04; A61P31/04; C07D491/048; C07K7/06; (IPC1-7): C07K7/06; A61K38/00; A61P3/10; A61P9/00; A61P9/04; A61P31/04; C12P21/02
Other References:
JPN6010058607, Ｊ． Ａｎｔｉｂｉｏｔ．， ｖｏｌ． ４９， ｐａｇｅｓ １３−１９ （１９９６）
JPN6010058608, Ｊ． Ａｎｔｉｂｉｏｔ．， ｖｏｌ． ４９， ｐａｇｅｓ ３７４−３７９ （１９９６）
JPN6010058609, Ｊ．Ｂｉｏｌ． Ｃｈｅｍ．， ｖｏｌ． ２７２， ｐａｇｅｓ ２３６９６−２３７０２ （１９９７）
JPN6010058608, Ｊ． Ａｎｔｉｂｉｏｔ．， ｖｏｌ． ４９， ｐａｇｅｓ ３７４−３７９ （１９９６）
JPN6010058609, Ｊ．Ｂｉｏｌ． Ｃｈｅｍ．， ｖｏｌ． ２７２， ｐａｇｅｓ ２３６９６−２３７０２ （１９９７）
Attorney, Agent or Firm:
Chika Takagi
Kosuke Nishimura
Hiroshi Sugimoto
Kosuke Nishimura
Hiroshi Sugimoto