Title:
疎水性多重複合ヘパリン結合体、その製造方法及び用途
Document Type and Number:
Japanese Patent JP2004512397
Kind Code:
A
Abstract:
The present invention provides hydrophobic heparin conjugates that are soluble in organic solvents but not in water, a method of preparing them, and a method of using them. Particularly, the present invention provides hydrophobic heparin conjugates that are prepared by covalently binding a polymer to heparin and a hydrophobic agent to the polymer. The hydrophobic heparin conjugates of the present invention maintain a good antithrombogenic effect and are insoluble in water due to their hydrophobicity, so they can be effectively used as coating agents for modifying the surfaces of medical devices.
Inventors:
Byun Yang Lo
Mon Hyun Tae
Mon Hyun Tae
Application Number:
JP2002537363A
Publication Date:
April 22, 2004
Filing Date:
November 03, 2000
Export Citation:
Assignee:
Mediplex Corporation Korea
International Classes:
A61L33/10; A61L27/00; A61L27/34; A61L33/00; C07K14/47; C08B37/00; C08B37/10; C08G81/00; (IPC1-7): C08G81/00; A61L33/10; C07K14/47; C08B37/10
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Kazunori Hashimoto