Title:
パクリタクセルとセフアロマンニンのクロマトグラフ分離法
Document Type and Number:
Japanese Patent JP2004514715
Kind Code:
A
Abstract:
A method for separating paclitaxel from cephalomannin and other related compounds by obtaining a starting material that contains paclitaxel and cephalomannin; dissolving the starting material in any one of a number of particularly defined solvents such as butyl formate and butyl acetate to form a mixture; subjecting the mixture to column chromatography to obtain an eluted fraction of paclitaxel, an eluted fraction of cephalomannin and a residue; and separately drying the paclitaxel and cephalomannin fractions to obtain separate crystalline forms of paclitaxel and cephalomannin, respectively.
Inventors:
Gabbetta, Bruno
Zini, Giann Franco
Zini, Giann Franco
Application Number:
JP2002546532A
Publication Date:
May 20, 2004
Filing Date:
November 09, 2001
Export Citation:
Assignee:
Indena Esse Pia
International Classes:
A61K31/337; A61P35/00; C07D305/14; (IPC1-7): C07D305/14; A61P35/00
Attorney, Agent or Firm:
Nobuyuki Kaneda
Katsuhiro Ito
Ishibashi Masayuki
Katsuhiro Ito
Ishibashi Masayuki