Title:
ペプチド模倣プロテアーゼインヒビター
Document Type and Number:
Japanese Patent JP2004517047
Kind Code:
A
Abstract:
The present invention relates to peptidomimetic compounds useful as protease inhibitors (1), particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.
Inventors:
Robert Edward Bavine
Shu Hui Chen
Jason Eric Lamar
Nancy June Snyder
Sun Shi Chen
Mark Joseph Thebb
Franz Victor
Kew May One
Yp Yvonne Ye Mai
Ivan Collado
Christina Garcia-Paredes
Raymond Samuel Parker The Third
Jin Lin
Dequi Guo
John Irvine Glass
Shu Hui Chen
Jason Eric Lamar
Nancy June Snyder
Sun Shi Chen
Mark Joseph Thebb
Franz Victor
Kew May One
Yp Yvonne Ye Mai
Ivan Collado
Christina Garcia-Paredes
Raymond Samuel Parker The Third
Jin Lin
Dequi Guo
John Irvine Glass
Application Number:
JP2002523884A
Publication Date:
June 10, 2004
Filing Date:
August 31, 2001
Export Citation:
Assignee:
ELI LILLY AND COMPANY
International Classes:
C12N9/99; A61K31/13; A61K31/437; A61K31/7052; A61K31/713; A61K38/00; A61K38/04; A61K38/05; A61K38/21; A61K38/55; A61K45/00; A61P1/16; A61P31/14; A61P43/00; C07D209/02; C07D209/52; C07K5/02; C07K5/023; C07K5/027; C07K5/03; C07K5/04; C07K5/06; C07K7/02; C07K7/06; C07K14/18; C12N7/06; A61K; A61P; C07K; (IPC1-7): C07K5/02; A61K31/13; A61K31/437; A61K31/7052; A61K31/713; A61K38/00; A61K38/21; A61K38/55; A61K45/00; A61P1/16; A61P31/14; A61P43/00; C07K5/023; C07K5/027; C07K5/03; C07K7/02; C12N7/06
Foreign References:
| WO1998017679A1 | 1998-04-30 | |||
| WO1999007733A2 | 1999-02-18 | |||
| WO1999007734A2 | 1999-02-18 | |||
| WO2000009558A1 | 2000-02-24 | |||
| WO1998017679A1 | 1998-04-30 | |||
| WO1999007733A2 | 1999-02-18 | |||
| WO1999007734A2 | 1999-02-18 | |||
| WO2000009558A1 | 2000-02-24 |
Other References:
JPN6010023011, Ｂｉｏｏｒｇ． Ｍｅｄ． Ｃｈｅｍ． Ｌｅｔｔ．, 1998, ｖｏｌ．８， ｎｏ．１９, ｐ．２７１９−２７２４
JPN6010023013, Ｂｉｏｏｒｇ． Ｍｅｄ． Ｃｈｅｍ． Ｌｅｔｔ．, 200004, ｖｏｌ．１０， ｎｏ．８, ｐ．７１１−７１３
JPN6010023013, Ｂｉｏｏｒｇ． Ｍｅｄ． Ｃｈｅｍ． Ｌｅｔｔ．, 200004, ｖｏｌ．１０， ｎｏ．８, ｐ．７１１−７１３
Attorney, Agent or Firm:
Aoyama Aoi
Osamu Kawamiya
Kyousei Tamura
Hiromitsu Takayama
Osamu Kawamiya
Kyousei Tamura
Hiromitsu Takayama