Title:
エリスロマイシン誘導体の合成におけるアリールチオイミン類の利用方法
Document Type and Number:
Japanese Patent JP2004520315
Kind Code:
A
Abstract:
An efficient deoximation technique for use in synthesis of erythromycin derivatives, involving aryl thioimine intermediates is disclosed. The aryl thioimine intermediates can be utilized in a method for protecting a ketone of a ketone-containing erythromycin derivative as a thioimine; a method for deoximating an oxime-containing erythromycin derivative, or a method for preparing a 6-O-alkyl erythromycin derivative. Presently preferred erythromycin derivatives have a C-9 oxime or a C-9 ketone.
Inventors:
Rookin, Kirill A
Application Number:
JP2002551986A
Publication Date:
July 08, 2004
Filing Date:
December 19, 2001
Export Citation:
Assignee:
ABBOTT LABORATORIES
International Classes:
A61K31/7048; A61P31/04; C07B61/00; C07H17/08; (IPC1-7): C07H17/08; A61P31/04
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura