Title:
ジヒドロ葉酸レダクターゼ阻害剤として使用するためのジアミノキナゾリンエステル類
Document Type and Number:
Japanese Patent JP2004520414
Kind Code:
A
Abstract:
Compounds of the formula I: wherein R1, R2, R1' and R2' are independently hydrogen or a group releasing the free amine in vivo, R6 is a substituted phenyl or an optionally substituted, bicyclic or tricyclic aryl ring system or an optionally substituted mono, bi- or tricyclic heteroaryl ring system having utility as DHFR inhibitors with favourable pharmacokinetic properties.
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Inventors:
Lundstedt, Torbjorn
Helgren, Aneri
Andersen, Pale
Halberg, Andaz
Nordberg, Merlin, Grafner
Helgren, Aneri
Andersen, Pale
Halberg, Andaz
Nordberg, Merlin, Grafner
Application Number:
JP2002567911A
Publication Date:
July 08, 2004
Filing Date:
February 28, 2002
Export Citation:
Assignee:
MERACURE Therapeutics AB
International Classes:
A61K31/517; A61P1/04; A61P11/00; A61P11/06; A61P15/00; A61P17/06; A61P19/02; A61P29/00; A61P31/04; A61P33/02; A61P35/00; A61P37/06; A61P43/00; C07D239/95; C07D405/12; C07D407/12; C07D409/12; (IPC1-7): C07D239/95; A61K31/517; A61P1/04; A61P11/00; A61P11/06; A61P15/00; A61P17/06; A61P19/02; A61P29/00; A61P31/04; A61P33/02; A61P35/00; A61P37/06; A61P43/00; C07D407/12; C07D409/12
Attorney, Agent or Firm:
Ikeuchi, Sato & Partners