Title:
免疫抑制された患者のためのワクチン免疫療法
Document Type and Number:
Japanese Patent JP2004521867
Kind Code:
A
Abstract:
A method for overcoming mild to moderate immune suppression includes the steps of inducing production of naive T-cells and restoring T-cell immunity. A method of vaccine immunotherapy includes the steps of inducing production of naive T-cells and exposing the naive T-cells to endogenous or exogenous antigens at an appropriate site. Additionally, a method for unblocking immunization at a regional lymph node includes the steps of promoting differentiation and maturation of immature dendritic cells at a regional lymph node and allowing presentation of processed peptides by resulting mature dendritic cells, thus, for example, exposing tumor peptides to T-cells to gain immunization of the T-cells. Further, a method of treating cancer and other persistent lesions includes the steps of administering an effective amount of a natural cytokine mixture as an adjuvant to endogenous or exogenous administered antigen to the cancer or other persistent lesions.
Inventors:
Hadden, John W..
Application Number:
JP2002537179A
Publication Date:
July 22, 2004
Filing Date:
October 26, 2001
Export Citation:
Assignee:
Immuno-Rx, Inc.
International Classes:
A61K45/00; A61K31/192; A61K31/365; A61K31/405; A61K31/415; A61K31/664; A61K38/00; A61K38/19; A61K39/00; A61K39/39; A61P31/00; A61P35/00; C12N15/19; C12P21/08; (IPC1-7): A61K39/00; A61K31/192; A61K31/365; A61K31/405; A61K31/415; A61K31/664; A61K38/00; A61K45/00; A61P31/00; A61P35/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita