抗炎症活性および抗アテローム生成活性を示すカワミドリ抽出物およびそれから単離され、精製されたチリアニンを含有する組成物

Japanese Patent JP2004521933

A

This invention includes a composition of Agastache rugosa and tilianin obtained by separation-purification for anti-inflammation and anti-atherosclerosis, and more particularly, an extract of Agastache rugosa and tilianin obtained therefrom by separation-purification which are effective in preventing and treating not only inflammatory diseases but also atherosclerosis related to inflammatory responses and disease in the circulatory system caused by atherosclerosis because they are excellent in inhibiting the activity of complement systems as a factor of inflammatory responses, the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecular-1 (VCAM-1), and the production of nitric oxide (NO). They can also significantly reduce the development of atherosclerosis due to the inflammatory response.

Lee Hyun Kyu
Oh Seiryan
Unkyun Soap
Choi Soon Ja
Kim Jun Hee
Ougu Taegu
Hong Jun Joo
Park Son Kyu
Nam Kang Woo

JP2002573027A

July 22, 2004

December 20, 2001

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KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

A23L1/30; A61K31/7048; A61K36/53; A61K36/532; A61P9/10; A61P29/00; A61P43/00; (IPC1-7): A61K35/78; A23L1/30; A61K31/7048; A61P9/10; A61P29/00; A61P43/00

JPH08176002A	1996-07-09
JPH10298098A	1998-11-10

SEI RYANG OH ET AL: "In Vitro Anticomplementary Activity of Phenylpropanoids from Agastache rugosa", KO. J. PHARMACOGN., vol. 27, no. 1, JPN4007021956, 1996, pages 20 - 25, XP053013352, ISSN: 0000900717
SEI RYANG OH ET AL: "In Vitro Anricomllementary Activity of Phenylprpanoids from Agastanche rugosa", KOR.J.PHARMACOG., vol. 27, no. 1, JPN6008005030, 1996, pages 20 - 25, ISSN: 0000973759

Minoru Nakamura
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda

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