Title:
修飾されたタキキニンレセプター
Document Type and Number:
Japanese Patent JP2004531215
Kind Code:
A
Abstract:
The invention provides a modified tachykinin receptor in which the three amino acids of the DRY sequence that occurs adjacent to the junction of the TM3 domain with intracellular loop 2 are replaced with amino acids whose side chains are neither lipophilic nor contain charged groups. The receptor exhibits similar ligand binding characteristics to the wild type receptor but is incapable or substantially incapable of initiating an endogenous signal. Thus the ligand exhibits no or substantially no intra-cellular coupling of the receptor to the G protein, whereby there is substantially no transduction of ligand binding signals to the cell, The invention also includes fragments of the receptor containing the modified DRY sequence, and polynucleotides that encode the modified receptor as aforesaid. Therapeutic and diagnostic uses for the receptor are disclosed.
Inventors:
Hall, Matthew Duncan
McNulty, Shaun
Murray, James Hummer
Suman-Chowhan, Namara
McNulty, Shaun
Murray, James Hummer
Suman-Chowhan, Namara
Application Number:
JP2002552008A
Publication Date:
October 14, 2004
Filing Date:
December 05, 2001
Export Citation:
Assignee:
WARNER-LAMBERT COMPANYLLC
International Classes:
G01N33/50; A61K9/12; A61K35/74; A61K35/76; A61K38/04; A61K38/17; A61K38/22; A61K48/00; A61P1/00; A61P1/04; A61P11/06; A61P19/02; A61P25/00; A61P25/06; A61P25/18; A61P25/22; A61P29/00; A61P43/00; C07K14/705; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/02; C12Q1/02; G01N33/15; G01N33/94; (IPC1-7): C12N15/09; A61K9/12; A61K35/74; A61K35/76; A61K38/22; A61K48/00; A61P1/04; A61P11/06; A61P19/02; A61P25/06; A61P25/18; A61P25/22; A61P29/00; A61P43/00; C07K14/705; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12Q1/02; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takashi Nakata
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takashi Nakata