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Patent Searching and Data

Document Type and Number:
Japanese Patent JP2004532184
Kind Code:
The present invention provides nucleoside derivatives (principally uracil, cytosine and uridine derivatives) which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside derivatives of the present invention.

Carroll, Stephen S
Rough Emina, Robert El
Hall, Dawn El
Himelberger, Amy El
Kuo, Lawrence Sea
Matsukos, Malcolm
Olsen, David Bee
Rutkowski, Carrier A
Tomasini, Giyoan Yi
Anne, Hao Yun
Bart, Barcelien
Nirima, Burt
Cook, Philip Dan
Eldratop, Anne Bee
Ginotsuso, Challes Jei
Purhaftsue, Mary
Placasille, Tarza Pea
Application Number:
Publication Date:
October 21, 2004
Filing Date:
January 18, 2002
Export Citation:
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Isis PharmaceuticalsInc
International Classes:
A61K31/519; A61K31/70; A61K31/7052; A61K31/706; A61K31/7064; A61K31/7068; A61K31/7076; A61K31/708; A61K31/7105; A61K31/712; A61K38/21; A61K45/00; A61K45/06; A61P1/16; A61P31/14; A61P43/00; C07D473/00; C07D487/02; C07H19/00; C07H19/04; C07D487/04; C07H19/048; C07H19/06; C07H19/067; C07H19/09; C07H19/10; C07H19/14; C07H19/16; C07H19/167; C07H19/173; C07H19/19; C07H19/20; C07H; C12N; (IPC1-7): A61K31/519; A61K31/7064; A61K31/7068; A61K31/708; A61K45/00; A61P31/14; A61P43/00; C07D487/04; C07H19/10; C07H19/20
Domestic Patent References:
Foreign References:
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura