Title:
コルチコトロピン放出因子アンタゴニスト
Document Type and Number:
Japanese Patent JP2004533465
Kind Code:
A
Abstract:
The present invention provides compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof wherein R is aryl or heteroaryl and each of the above groups R may be substituted by 1 to 4 groups selected from: halogen, C1-C6 alkyl, C1-C6 alkoxy, halo C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo C1-C6 alkoxy, -COR4, nitro, -NR3R4 cyano, or a group R5; R1 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo C1-C6 alkyl, halo C1-C6 alkoxy, halogen, NR3R4 or cyano; R2 corresponds to a group CHR6R7; R3 is hydrogen, C1-C6 alkyl; R4 independently from R3, has the same meanings; R5 is C3-C7 cycloalkyl, which may contain one or more double bonds; aryl; or a 5-6 membered heterocycle; wherein each of the above groups R5 may be substituted by one or more groups selected from: halogen, C1-C6 alkyl, C1-C6 alkoxy, halo C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo C1-C6 alkoxy, C1-C6 dialkylamino, nitro or cyano; R6 is hydrogen, C2-C6 alkenyl or C1-C6 alkyl, wherein each of the above groups R6 may be substituted by one or more groups selected from: C1-C6 alkoxy and hydroxy; R7 independently from R6, has the same meanings; X is carbon or nitrogen; to processes for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of conditions mediated by corticotropin-releasing factor (CRF).
Inventors:
Romano di Fabio
Chiara Marchionni
Fabrizio Micheli
Alessandra Pasqualello
Benedetta Perini
Yves Sun-Deni
Chiara Marchionni
Fabrizio Micheli
Alessandra Pasqualello
Benedetta Perini
Yves Sun-Deni
Application Number:
JP2003503630A
Publication Date:
November 04, 2004
Filing Date:
June 11, 2002
Export Citation:
Assignee:
GLAXO GROUP LIMITED
International Classes:
A61K31/519; A61K51/00; A61K51/04; A61P1/04; A61P25/00; A61P25/22; A61P25/24; A61P43/00; C07D239/70; C07D239/94; C07D471/04; C07D487/04; (IPC1-7): C07D487/04; A61K31/519; A61K51/00; A61P1/04; A61P25/22; A61P25/24; A61P43/00
Attorney, Agent or Firm:
Mitsuo Tanaka
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Mina Shiga
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Mina Shiga
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