Title:
ワクチン製造のためにその生体膜の持続的遺伝子改変によって病原微生物から非毒性微生物を生成する方法
Document Type and Number:
Japanese Patent JP2004535184
Kind Code:
A
Abstract:
Here we describe a methodology to generate non virulent microorganisms from pathogenic ones through permanent genetic modification of the physical state of their membrane (MPS). Thus, at the onset of infection, in these transformed organisms, as they infect a host (e.g. a target cell of a higher eukaryote, particularly mammals, and more specifically human cells, or injecting them in a model of animal infection, the expression of heat shock (stress) genes and the accumulation of the coded proteins (stress proteins or HSPs) and that of other species-specific gene products, the regulation is altered as a consequence of the coded modification of MPS. Among others, we refer also to genes whose regulation is mediated by signaling transduction pathways. Therefore, as a result of this procedure, pathogens became non-virulent (attenuated, live microorganisms) that can be used for vaccine production.
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Inventors:
Cinque Grani Roberto
Cologna Romano Sergio
Cologna Romano Sergio
Application Number:
JP2003500248A
Publication Date:
November 25, 2004
Filing Date:
May 29, 2002
Export Citation:
Assignee:
Blane Tech Society A Responsor Sabilita Limitata
International Classes:
A61K39/00; A61K39/005; A61K39/008; A61K39/015; A61K39/02; A61K39/04; A61K39/085; A61K39/09; A61K39/095; A61K39/10; A61K39/102; A61K39/106; A61K39/108; A61K39/112; A61P31/04; A61P31/10; A61P33/00; C12N1/21; C12N9/02; C12N15/09; C12N15/12; (IPC1-7): C12N15/09; A61K39/00; A61K39/005; A61K39/008; A61K39/015; A61K39/02; A61K39/04; A61K39/085; A61K39/09; A61K39/095; A61K39/10; A61K39/102; A61K39/106; A61K39/108; A61K39/112; A61P31/04; A61P31/10; A61P33/00; C12N1/21
Attorney, Agent or Firm:
Jyohei Yamashita