Title:
R-及びS-シタロプラムの混合物を分離することによってラセミシタロプラム及び/またはS-もしくはR-シタロプラムを製造する方法
Document Type and Number:
Japanese Patent JP2004536093
Kind Code:
A
Abstract:
The invention relates to a process for the preparation of racemic citalopram free base or an acid addition salt thereof and/or R- or S-citalopram as the free base or an acid addition salt thereof by separation of a mixture of R- and S-citalopram with more than 50% of one of the enantiomers into a fraction consisting of racemic citalopram and/or a fraction of S-citalopram or R-citalopram characterized in that i) citalopram is precipitated from a solvent as the free base or as an acid addition salt thereof; ii) the precipitate formed is separated from the mother liquor; iia) if the precipitate is crystalline it is optionally recrystallised one or more times to form racemic citalopram, and then optionally converted into an acid addition salt thereof; iib) if the precipitate is not crystalline, steps i) and ii) are optionally repeated until a crystalline precipitate is obtained and the crystalline precipitate is recrystallised one or more times to form racemic citalopram, and then optionally converted into an acid addition salt thereof; iii) the mother liquor is optionally subjected to further purification and S-citalopram or R-citalopram is isolated from the mother liquor and optionally converted into an addition salt thereof.
Inventors:
Humbre ricke eva
Christensen Troelus Volsgaard
Rock Michael Harold
Nielsen Ole
Petersen Hans
Dancer robert
Christensen Troelus Volsgaard
Rock Michael Harold
Nielsen Ole
Petersen Hans
Dancer robert
Application Number:
JP2003507077A
Publication Date:
December 02, 2004
Filing Date:
June 25, 2002
Export Citation:
Assignee:
Her Lundbeck Actiezer Scabet
International Classes:
A61K31/343; A61P25/24; C07B57/00; C07C253/30; C07D307/87; C07D307/93; C07D; (IPC1-7): C07D307/87; A61P25/24
Attorney, Agent or Firm:
Mitsufumi Esaki
Tsuneo Mihara
Okumura Yoshimichi
Blacksmith
Tsuneo Mihara
Okumura Yoshimichi
Blacksmith